such as "Introduction", "Conclusion"..etc
1S.V.K.M'S, Dr. Bhanuben Nanavati College of Pharmacy, Mithibhai College Campus, V.M.Road. Vile Parle- (W), Mumbai - 400 056. (India), Fax: 91-022-26132905, Email:[email protected][email protected]
2C.U.Shah College of Pharmacy, S.N.D.T Women's University, Sir Vithaldas Vidyavihar, Santacruz (West), Mumbai-400049. Fax: 91-22-2660 3968
Submitted to Biology-Online.org on 2008 March 02 Published in Biology-Online.org on 2008 March 18
Anti-Inflammatory Activity of the fruits of Piper nigrum, Linn and roots of Ricinus communis, Linn using the carrageenan induced rat paw edema method.
Inflammation is a response of vascularised living tissue to the local injury. It is the body defense mechanism, which is closely intertwined with the process of repair. It serves to destroy or dilute the injurious agents and also reconstitute the damaged tissue by regeneration.
The severe side effects of steroidal and non-steroidal anti-inflammatory drug evoked us to search for new anti-inflammatory drugs from the natural botanical source. Thus, the present investigation was carried out to evaluate anti-inflammatory activity of extracts of Piper nigrum and Ricinus communis in rat paw edema method as an experimental animal model.
The drugs were authentified, powdered, and subjected to various solvent extractions using Soxhlet apparatus. The extracts were standardized and phytochemical examination was carried out using chemical and chromatographic method. The acute toxicity (LD50) was carried out for both the drug.
The anti-inflammatory activity of all the extracts were determined by using carrageenan induced rat paw edema method in comparison with aspirin as a reference synthetic anti-inflammatory drug.
The pet ether extract of Piper nigrum and Ricinus communis shows statistically significant anti- inflammatory activity than the other extract.
Piper nigrum and Ricinus communis effectively suppress the inflammation.
Inflammation, rat paw edema method, carrageenan, Piper nigrum and Ricinus communis
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