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<p> <span style="font-size:x-large;">Acknowledgements </span> </p> <p> <br> We thank James Campbell, John Manis, and Li Cai for helpful<sup></sup>discussions. D.Z. is supported by National Institutes of Health<sup></sup>(NIH) Training Grant HL066987. H.L. was supported by NIH Grants<sup></sup>NS052200 and GM076084 and a research scholar grant from American<sup></sup>Cancer Society.<sup></sup></p> <p> <a></a><span style="font-size:x-large;">Footnotes </span> </p> <p> Abbreviations: PI3K, phosphatidylinositol 3-kinase; PtdIns(3,4,5)P3, phosphatidylinositol 3,4,5-trisphosphate. </p> <p> <a></a>*To whom correspondence should be addressed. E-mail: <span><a href="mailto:hongbo.luo@childrens.harvard.edu">hongbo.luo@childrens.harvard.edu</a></span> </p> <p> Author contributions: H.R.L. designed research; D.Z., H.H.,<sup></sup>H.J., Y.J., K.K.S., F.L., and J.Y. performed research; Y.L.,<sup></sup>M.H., and L.S. contributed new reagents/analytic tools; D.Z.,<sup></sup>H.H., H.J., Y.J., K.K.S., F.L., and H.R.L. analyzed data; and<sup></sup>H.R.L. wrote the paper.<sup></sup></p> <p> The authors declare no conflict of interest.<sup></sup></p> <p> This paper was submitted directly (Track II) to the PNAS office.<sup></sup></p> <p> © 2006 by <a href="http://www.pnas.org/misc/terms.shtml">The National Academy of Sciences</a> of the USA </p>
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