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<h3>Article</h3> <h2>Genomic blueprint of <em>Hahella chejuensis</em>, a marine microbe producing an algicidal agent </h2> <strong>Haeyoung Jeong, Joung Han Yim<sup>3</sup>, Choonghwan Lee<sup>1</sup>, Sang-Haeng Choi, Yon Kyoung Park, Sung Ho Yoon, Cheol-Goo Hur, Ho-Young Kang, Dockyu Kim<sup>1</sup>, Hyun Hee Lee, Kyun Hyang Park, Seung-Hwan Park, Hong-Seog Park, Hong Kum Lee<sup>3</sup>, Tae Kwang Oh<sup>2</sup></strong>and<strong> Jihyun F. Kim<sup></sup></strong> <p><em>Genome Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) PO Box 115, Yuseong, Daejeon 305-600, Republic of Korea <sup>1</sup>Division of Drug Discovery, Korea Research Institute of Bioscience and Biotechnology (KRIBB) PO Box 115, Yuseong, Daejeon 305-600, Republic of Korea <sup>2</sup>21C Frontier Microbial Genomics and Applications Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB) PO Box 115, Yuseong, Daejeon 305-600, Republic of Korea <sup>3</sup>Korea Polar Research Institute, KORDI PO Box 29, Ansan, Seoul 425-600, Republic of Korea</em> </p> <p><em><sup></sup>To whom correspondence should be addressed. Tel: +82 42 860 4412; Fax: +82 42 879 8595; Email: <span><a href="mailto:jfk@kribb.re.kr">jfk@kribb.re.kr</a></span> </em></p> <p><em>Received November 2, 2005. Revised November 28, 2005. Accepted November 28, 2005.</em> </p> <p><a></a> </p> <p>Harmful algal blooms, caused by rapid growth and accumulation of certain microalgae in the ocean, pose considerable impacts on marine environments, aquatic industries and even public health. Here, we present the 7.2-megabase genome of the marine bacterium <em>Hahella chejuensis</em> including genes responsible for the biosynthesis of a pigment which has the lytic activity against a red-tide dinoflagellate. <em>H.chejuensis</em> is the first sequenced species in the <em>Oceanospiralles</em> clade, and sequence analysis revealed its distant relationship to the <em>Pseudomonas</em> group. The genome was well equipped with genes for basic metabolic capabilities and contained a large number of genes involved in regulation or transport as well as with characteristics as a marine heterotroph. Sequence analysis also revealed a multitude of genes of functional equivalence or of possible foreign origin. Functions encoded in the genomic islands include biosynthesis of exopolysacchrides, toxins, polyketides or non-ribosomal peptides, iron utilization, motility, type III protein secretion and pigmentation. Molecular structure of the algicidal pigment, which was determined through LC-ESI-MS/MS and NMR analyses, indicated that it is prodigiosin. In conclusion, our work provides new insights into mitigating algal blooms in addition to genetic make-up, physiology, biotic interactions and biological roles in the community of a marine bacterium. </p> <p><em>Nucleic Acids Research 2005 33(22):7066-7073</em><em>. Published by Oxford University Press. The online version of this article has been published under an open access model.</em> </p>
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