Multiple links between transcription and splicing
This review focuses on the roles of cis- and trans-acting factors that regulate transcription, on constitutive and alternative splicing.

Single translation—dual destination: mechanisms of dual protein targeting in eukaryotes
A review article that describes proteins that harbour one signal, two separate signals or an overlapping ambiguous signal may follow dual distribution in the cell.

Protein synthesis in eukaryotes: The growing biological relevance of cap-independent translation initiation
This review summarizes features of both cap-dependent and IRES-dependent mechanisms of translation initiation and discusses the role of cis-acting elements, which include the 5'cap, the 5'-untranslated region (UTR) and the poly(A) tail as well as the poss

Australian Scientists Crack DNA Replication Mystery
A team of scientists led by Professor Nick Dixon at the Research School of Chemistry at The Australian National University have cracked one of the great DNA mysteries...

Genes Can Answer To More Than One Master
Like discovering a car that has more than one engine under the hood, cell biologists are learning to their surprise that alternate molecular machines can drive the basic process of transcription that orchestrates the expression of genes...

Clearing Jams In Copy Machinery
Bacteria and humans use a number of tools to direct perhaps the most important function in cells -- the accurate copying of DNA during cell division.

Faulty DNA Replication Linked To Neurological Diseases
Lengthy sequences of DNA -- with their component triplet of nucleotides repeated hundreds, even thousands of times -- are known to be abnormal, causing rare but devastating neurological diseases...

Novel Mechanism For DNA Replication Discovered
Since the discovery of the structure of DNA by James Watson and FrancisCrick in 1953, the paradigm for DNA replication has stated that the DNA itself codes for the appropriate pairings for replication.

Important DNA Repair Mechanism Linked To Premature Aging Yields
New players in the first steps of transcription-coupled repair (TCR), an essential but still mysterious mechanism of DNA repair, were discovered...

New Gene Regulation Mechanism Discovered
A new kind of messenger RNA molecule that is converted from non-protein coding status to protein coding status in response to cellular stress such as viral infection was discovered.

Putting Muscle In The Nucleus
The presence of a "molecular motor" inside the nucleus, where it appears to be powering the assembly line that forges RNA messages off of the long DNA templates was found...

Jefferson Scientists Show “Dachshund” Gene Reverts Cancer Genes to Normal, Predicts Breast Cancer Prognosis
Scientists have shown that the activity of a gene that commandeers other cancer-causing genes, returning them to normal, can predict the prognosis of an individual with breast cancer.

Cellular Dumping Site Is Not Garbage After All
Cells can reuse the chemical messengers that carry genetic information to the machinery that makes proteins. Sometimes cells shuttle the messengers to storage and later reactivate them to make proteins, according to new research...

Targeting Transcription: New Insights Into Turning Genes On
The 35,000 or so genes within a human cell are something like players on a sports team: If their activity isn't controlled and coordinated, the result can be disastrous...

Cells Are Resourceful When It Comes To Copying DNA, Even When The DNA Is Damaged
Billions of cells divide every day in our bodies to replace those that wear out. To be able to do so, their DNA must be copied...

Viral Discovery and Sequence Recovery Using DNA Microarrays
The advent of the DNA-microarray based methods has led to discovery and identification of many emerging infectious agents particulary virus, including its genomic sequence.

Osteoarthritis may be sign of faster 'biological ageing'
Osteoarthritis, the degenerative inflammatory bone disease, may be a sign of faster "biological ageing," suggests research.

More GC Means More RNA
More GC Means More RNA
Richard Robinson

The genetic code that dictates the translation of RNA triplets into amino acids is rife with synonyms.

When it comes to gene transcription, random pauses aren’t quite so random, study finds
team found that a molecule of RNAP makes frequent pauses at specific sites along the DNA double helix.