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Bioinformatics is an information technology applied in biological research to store, collect and retrieve biologically oriented data, to analyze and predict the composition of molecules (nucleic acids, proteins, etc.), and to model biological systems through mathematical, statistical and computer methods. Major studies in this field include sequence alignment, gene finding, genome assembly, protein structure alignment, protein structure prediction, prediction of gene expression and protein-protein interactions, and the modeling of evolution.

Bioinformatics Articles

DOE JGI upgrades IMG/M -- the Metagenomics Data Management & Analysis System
On the one-year anniversary of the launch of the experimental metagenome data management and analysis system, IMG/M, the U.S. Department of Energy Joint Genome Institute (DOE JGI) has released the latest upgrade.

Date: 1 Dec 2007, Rating: not rated

Uniform language for describing genes of pathogenic and beneficial microbes
An international group of scientists has announced a major expansion of a lingua franca used to describe the activities of genes in living organisms.

Date: 27 May 2007, Rating: 2.50

Virginia Bioinformatics Institute launches microbial database
Researchers at the Virginia Bioinformatics Institute at Virginia Tech have launched a publicly-available microbial database to host a range of microbial genome sequences.

Date: 27 May 2007, Rating: 5.00

UkeU, Leeds and Manchester launch global masters programme in bioinformatics
The universities of Leeds and Manchester will provide a new masters course in bioinformatics for UKeU. Leeds and Manchester are developing the course

Date: 27 May 2007, Rating: not rated

Large DNA microarray dataset is made publicly available by LGC and the European Bioinformatics Institute (EBI)
A large DNA microarray dataset generated by an LGC-led consortium during the first phase is now freely available online at ArrayExpress

Date: 27 May 2007, Rating: 1.00

LIAI finding gives boost to bioinformatics use in fighting disease
The use of computers to advance human disease research — known as bioinformatics — has received a major boost from researchers at the La Jolla Institute for Allergy & Immunology

Date: 27 May 2007, Rating: 2.00

Oil exploration and drug discovery to benefit from NuTec/Daresbury high performance computing deal
More accurate prediction of the location of oil reserves and faster screening of potential new drugs could result from a new collaborative agreement between NuTec Sciences Ltd. and Daresbury Laboratory.

Date: 27 May 2007, Rating: not rated

Spanish scientists reveal dynamic map of proteins
This work provides important basic information on the flexibility of proteins and their ability to link with other molecules, an area of study which opens enormous possibilities for the design of new drugs

Date: 27 May 2007, Rating: not rated

Web model of influenza-host lifecycles will aid scientists in creating anti-viral drugs
A "starry sky" map linking the myriad interactions between the influenza virus and its human host will help guide researchers in creating new anti-viral drugs

Date: 27 May 2007, Rating: 1.00

Virginia Bioinformatics Institute to develop Tomato Metabolite Database
A researcher is developing a database and computational tools to help scientists learn more about how certain genes in tomatoes affect the crop's flavor and nutritional value.

Date: 27 May 2007, Rating: 2.00

Quantum Biology: Powerful Computer Models Reveal Key Biological Mechanism
Using powerful computers to model the intricate dance of atoms and molecules, researchers at Rensselaer Polytechnic Institute have revealed the mechanism behind an important biological reaction.

Date: 1 Feb 2007, Rating: 7.13

Tearing down the fungal cell wall
Scientists have pinpointed a fungal gene that appears to play an important role in the development and virulence of Alternaria brassicicola.

Date: 31 Jan 2007, Rating: 2.00

Proteins may predict lung transplant rejection
Using the latest in high tech tools, researchers have identified three proteins that were highly predictive of chronic lung rejection up to 20 months before the rejection occurred.

Date: 24 Jan 2007, Rating: not rated

Mining yeast in silico unearths a golden nugget for mitochondrial biology
The research described here combines clever model organism genomics and bioinformatics with sophisticated human molecular and biochemical genetics to identify the first mammalian protein required for the normal assembly of complex I.

Date: 23 Jan 2007, Rating: not rated, 5 pages

Computers to save unique type of American red squirrel
UK expertise is being exported to North America to help prevent a unique type of red squirrel dying out in as little as 30 years time.

Date: 20 Sep 2006, Rating: 3.00

Experimental and bioinformatic approaches for interrogating protein–protein interactions to determine protein function
The authors presented an overview of different experimental and bioinformatic methods to elucidate protein–protein interactions.

Date: 14 Aug 2006, Rating: 5.00, 7 pages

Computational cluster validation in post-genomic data analysis
This review paper aims to familiarize the reader with the battery of techniques available for the validation of clustering results, with a particular focus on their application to post-genomic data analysis.

Date: 14 Aug 2006, Rating: 6.17, 11 pages

From genome to epigenome
The authors reviewed the current thinking and progress on how to get from the genome to the epigenome(s) and discuss some potential applications.

Date: 14 Aug 2006, Rating: 6.20, 8 pages

Bioinformatics as a critical prerequisite to transcriptome and proteome studies
This paper will provide some examples of misleading annotations with regard to putative protein function that may cause mistakes either in array design or in data interpretation.

Date: 14 Aug 2006, Rating: 1.00, 8 pages

Bioinformatics opportunities for health sciences librarians and information professionals
The aim of this brief communication is to assist health sciences librarians with finding training programs and to give examples of how some libraries are currently expanding services to support bioinformatics research.

Date: 14 Aug 2006, Rating: 2.60, 7 pages