Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
Nucleic acid ligands (referred to as aptamers) are short DNA or RNA fragments that can bind to target antigens with high specificity and affinity

A real time look at interactions between RNA and proteins
For the first time, researchers can now peer inside intact cells to not only identify RNA-binding proteins

Dinosaur DNA? New Patent Covers Degraded DNA recovery
The US Patent Office issued Patent # 6,872,552, "A Method of Reconstituting Nucleic Acid Molecules" today to Burt D. Ensley, Ph.D, Chairman of MatrixDesign, and CEO of DermaPlus, Inc

Synthesis and Use of Modified Peptide Nucleic Acids for Visual Detection of DNA
Modification of peptide nucleic acids (PNAs) by the incorporation of trans-1,2-diaminocyclopentane into the PNA provides for more highly sensitive and selective detection of DNA and RNA sequences.

Nucleic Acid-Amplification Testing Further Safeguards Nation's Blood Supply, NHLBI Study Shows
State-of-the-art testing systems to screen donated blood have improved the safety of the nation's blood supply by preventing the transmission of potentially deadly viruses

Nucleotide Excision Repair and Cancer
ABSTRACT: Enviromental or endogenous DNA damages of genomic DNA are either repaired by DNA repair mechanisms or lead apoptosis in living organisms.

Human MicroRNA Targets
Their analysis suggests that miRNA genes, which are about 1% of all human genes, regulate protein production for 10% or more of all human genes.

MicroRNA: Biogenetic and Functional Mechanisms and Involvements in Cell Differentiation and Cancer
In this review, recent remarkable advances in the miRNA biogenetic and functional mechanisms and the involvements of miRNAs in cell differentiation, especially in hematopoietic lineages, and cancer were discussed.

On the Biological Significance of DNA Methylation
This chapter presents a personal account of the work on DNA methylation in viral and mammalian systems performed in the author's laboratory in the course of the past thirty years.

Mutation of exposed hydrophobic amino acids to arginine to increase protein stability
The study aimed to test the increase in stability of proteins by reducing the area of water-accessible hydrophobic surface...