Chemical accuracy in QM/MM calculations on enzyme-catalysed reactions
Combined quantum mechanics/molecular mechanics (QM/MM) modelling has the potential to answer fundamental questions about enzyme mechanisms and catalysis.

Thiamine diphosphate adenylyl transferase from E. coli: functional characterization of the enzyme synthesizing adenosine thiamine triphosphate
This is the first demonstration of an enzyme activity transferring a nucleotidyl group on thiamine diphosphate to produce AThTP.

Pick your COX partners
COX enzymes work together in ways that suggest new biological roles, drug targets

Scientists Discover First Bacterial Enzyme That Activates Blood-Clotting -- Links Gum Health And Heart Disease In Humans
Scientists at the University of Georgia have discovered that an enzyme in a common bacterium is capable of activating blood-clotting in the human body.

Max-Planck Researchers Unravel The Structure Of The Methane Forming Enzyme
Max-Planck researchers unravel the structure of the methane forming enzyme

Increased Amount Of Enzyme In Brain May Be Marker Of Alzheimer's Disease
An enzyme present in extremely low quantities in normal brains has been found to be greatly increased in the brains of patients with Alzheimer's disease.

Obscure Enzyme May Play Major Role In Heart Disease
A little-known enzyme may play a significant role in preventing heart attack.

Naturally Produced Enzyme May Be Useful In Inflammatory Arthritis
Researchers have discovered a potential method to help treat inflammatory forms of arthritis by using an enzyme naturally produced by the human body.

Constructing "Designer" Plant Enzymes
Their results represent a step toward the production of novel plant fatty acids by genetic manipulations.

Enzymology of Methylation of Tea Catechins and Inhibition of Catechol-O-methyltransferase by ()-Epigallocatechin Gallate
In this study, we characterized the enzymology of cytosolic catechol-O-methyltransferase (COMT)-catalyzed methylation of EGCG and EGC in humans, mice, and rats.

Automated Definition of the Enzymology of Drug Oxidation by the Major Human Drug Metabolizing Cytochrome P450s
A fully automated assay to determine the enzymology of drug oxidation by the major human hepatic cytochrome P450s

Evaluation of the dot enzyme-linked immunosorbent assay in comparison with standard ELISA for the immunodiagnosis of human toxocariasis
A dot enzyme-linked immunosorbent assay was standardized using excretory-secretory antigens of Toxocara canis for the rapid immunodiagnosis of human toxocariasis.

Modest induction of phase 2 enzyme activity in the F-344 rat prostate
Investigated if carcinogen defense (phase 2) enzymes could be induced in the prostate tissues of rats after oral feeding of candidate phase 2 enzyme inducing compounds.

Enzyme-linked immunoassay for dengue virus IgM and IgG antibodies in serum and filter paper blood
The reproducibilty of dengue IgM and IgG ELISA was studied in serum and filter paper blood spots from Vietnamese febrile patients.

Hyperglycemia alters enzyme activity and cell number in spinal sensory ganglia
Using transgenic mouse model of diabetes and controls to examine the histological effect of chronic hyperglycemia on the activity or abundance of the enzymes acid phosphatase, cytochrome oxidase and NADPH-diaphorase...

Cytochrome P450 enzyme isoforms and their therapeutic implications: An update
These isoenzymes are a major determinant of the pharmacokinetic behavior of numerous drugs.

Enzyme may hold key to new treatment of diabetic kidney disease
Researchers have found that an enzyme called ACE2 may hold the potential to treat diabetic kidney disease, the most common form of kidney disease.

Enzyme discovery may link underlying processes in cancer and heart disease
Scientists have discovered a new family of enzymes that appears to play a powerful role in generating the abnormal cell growth that occurs in both cancer and in some forms of cardiovascular disease.

Enzyme offers target to attack drug-resistant tuberculosis
Researchers have discovered an enzyme that allows the tuberculosis bacterium to metabolize nutrients and persist for months while shielding itself from immune-system attack by hiding inside macrophages.

Hopkins scientists show enzyme is key to hallmark of Alzheimer's
Scientists at Johns Hopkins have demonstrated that a specific enzyme in the brain is essential for nerve cells to form a hallmark of Alzheimer's disease