Yorkes autolytic reaction

Yorke's autolytic reaction

A test for paroxysmal haemoglobinuria; serum is placed in an ice chest and kept at 0�C for 5 to 7 minutes, then in an incubator at 37�C with erythrocytes for 1 hour, at which time, if the reaction is positive, haemolysis occurs; if the serum is kept at 1�C for an hour and then placed in the incubator with erythrocytes there is little haemolysis.

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