Wobble hypothesis

wobble hypothesis

(Science: molecular biology) explains why the base inosine is included in position 1 in the anticodons of various t rNAs, why many mRNA codon words translate to a single amino acid, why there are appreciably fewer t RNAs than mRNA codon types and why the redundant nature of the genetic code translates into a precise set of 20 amino acids.

inosine in position 1 in the anticodon can base pair with A, u or C in position 3 in the mRNA codon, so that for example UCU, UCC, UCA all code for serine using an inosine anticodon.

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