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Wobble base

Wobble base

The 3' codon base on mrna that is less strictly specified in the genetic code. For example GCA, GCC, GCG and GCU are all acceptable codons for alanine. In this case the third nucleotide is redundant and a small amount of silent Mutation is possible and tolerated.

See: wobble, wobble hypothesis.


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Wobble hypothesis.How does met & trp not get mis translated?

... tRNA molecule pairs with its complementary codon using Watson-Crick base pairing, then 61 different tRNA molecules would be required. But some tRNA molecules can recognize more than one codon due to Wobble base pairing and thus the number of tRNA molecules found in a cell is ...

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by Sue4
Tue Apr 10, 2012 4:30 pm
 
Forum: Molecular Biology
Topic: Wobble hypothesis.How does met & trp not get mis translated?
Replies: 2
Views: 5292

Wobble hypothesis.How does met & trp not get mis translated?

I understand the principle of the wobble hypothesis, that the last base pair between a mRNA codon and a tRNA anticodon is not as stringent as the DNA base pairing rules. ...

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by Awol
Sun Apr 08, 2012 6:33 pm
 
Forum: Molecular Biology
Topic: Wobble hypothesis.How does met & trp not get mis translated?
Replies: 2
Views: 5292

Replacing the genetic material

... more than one codon due to a phenomenon , i guess it's called "Wobble base pair" @kolean it reads form where the start codon is @Darby please , can you explain ...

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by truthSeeker
Sat Jul 03, 2010 11:45 am
 
Forum: Genetics
Topic: Replacing the genetic material
Replies: 9
Views: 5254

Re: genes change at a steady rate

... necessarily lead to a change in phenotype. A change in a nucleic acid base at a wobble position can be completely silent in terms of the resulting amino acid sequence. In ...

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by jonmoulton
Wed May 26, 2010 2:38 pm
 
Forum: Genetics
Topic: genes change at a steady rate
Replies: 3
Views: 2048

Re: I am afraid to ask but, High school freshman - Honors Class

For the specific question you asked, look into the term "wobble base". Your daughter is going to need to do a lot of reading quickly. That's good. Use Wikipedia ...

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by jonmoulton
Thu Sep 11, 2008 12:24 am
 
Forum: Molecular Biology
Topic: I am afraid to ask but, High school freshman - Honors Class
Replies: 17
Views: 19525
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