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Voltage clamp

voltage clamp

(Science: physiology, technique) A technique in electrophysiology, in which a microelectrode is inserted into a cell and current injected through the electrode so as to hold the cells membrane potential at some predefined level.

The technique can be used with separate electrodes for voltage sensing and current passing, for small cells, the same electrode can be used for both. Voltage clamp is a powerful technique for the study of ion channels.

See: patch clamp.

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Patch-Clamping - Need help in basics

... but at the moment I have to deal with some results of patch-clamp recordings. Unfortunately I've never been taught how to interpret those ... question is now: I have a cell in whole cell patch-clamp and do a voltage ramp. How do I have to interpret the measurement? I have, as a result, ...

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by Jennileinchen
Mon Jul 22, 2013 3:22 pm
Forum: Molecular Biology
Topic: Patch-Clamping - Need help in basics
Replies: 0
Views: 1147

neuro questions!

Whole-cell patch clamp electrophysiology can be used to record: a) the activity of the ion channels that ... in the patch of membrane b) the activity of multiple neurons at a given time c) voltage and/or current across the membrane of a cell d) multi-unit activity My guess: c. ...

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by yj90
Wed Jan 19, 2011 4:37 am
Forum: Physiology
Topic: neuro questions!
Replies: 2
Views: 4520

Neurobiology Questions

... I need help on the following questions. Please help. Thank you. 1. In a voltage clamp experiment, Hodgkin and Huxley first clamped an axon at 0 mv and then at +60 mV. Assuming ...

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by biol245
Fri Sep 24, 2010 2:29 pm
Forum: Cell Biology
Topic: Neurobiology Questions
Replies: 0
Views: 4372

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