Vitronectin gene is mapped on chromosome 17q11 consisting of 459 amino acids that belong to the integrin family acts as a cell-substrate adhesion molecule. Its structure is composed of acidic N-terminal region which represents the macromolecular binding sites and the basic C-terminal region signifies the heparin binding sites. About one-third of this protein’s molecular mass contains carbohydrates exists in both single chain form and two chain form seized jointly by a disulfide bond.
Vitronectin has been proven to preserve pluripotency and normal growth characteristics in numerous pluripotent stem cell lines without any signs of karyotypic abnormalities and uphold the ability to differentiate into germ line lineages. It also binds to heparin and thrombin-antithrombin III complexes involved in the immune response and regulation of clot formation.
Vitronectin has Arg-Gly-Asp recognition sequence that is structurally and immunologically distinct which is modulated by proteolytic enzymes by exo-ecto protein kinase in the blood involved in cell attachment, migration and spreading revealing as therapeutic agents in the treatment of human bone diseases, cancers and angiogenesis.
Gene name: VTN
Protein name: Vitronectinb(VN)