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Variable region

variable region --> V region

(Science: molecular biology) Those regions in the amino acid sequence of both the heavy and the light chains of immunoglobulins where there is considerable sequence variability from one immunoglobulin to other of the same class, in contrast to constant sequence (C) regions. The v regions are associated with the antigen binding areas. They contain hypervariable regions of particularly high sequence diversity.

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Re: Any ideas for vaccine development or anti-viral drugs???

... A 22-mer P-PMO designed to base pair with the translation start site region of EBOV VP35 positive-sense RNA generated sequence-specific and time- ... PMO chemical modifications that included conjugation with peptides of variable length and composition, positioning of conjugated peptides to either ...

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by jonmoulton
Mon Sep 15, 2014 3:04 pm
Forum: Cell Biology
Topic: Any ideas for vaccine development or anti-viral drugs???
Replies: 2
Views: 12575


... 24 different binding loci. Each forward and reverse pair spans a region that has a variable number of base pairs between individuals, but a given individual will have a definite ...

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by jonmoulton
Tue Jan 29, 2013 4:16 pm
Forum: Genetics
Topic: PCR
Replies: 2
Views: 3585

CE sequencing and primers

... study difference in sequences, my primers must be confined out of the variable regions, because: - annealing, as in if the sequence change, the annealing will be modified ...

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by canalon
Tue Dec 13, 2011 4:07 pm
Forum: Molecular Biology
Topic: CE sequencing and primers
Replies: 1
Views: 1007


To help you along you way, think about the ways in which the variable region of the Ig may be changed and that may adjust its binding properties. For the most part, ...

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by daniel.kurz
Mon Oct 24, 2011 12:35 am
Forum: Human Biology
Topic: immunology
Replies: 4
Views: 3419

Re: isoforms in cell line

... such a big range of molecules. Although if your target protein has some variable region or odd glycosylation patterns and your antibody only targets the "constant" ...

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by biohazard
Mon Jun 07, 2010 6:29 am
Forum: Cell Biology
Topic: isoforms in cell line
Replies: 4
Views: 3131
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