Dictionary » U » Ubiquitin


Ubiquitin is a small regulatory protein that is ubiquitous in eukaryotes. Ubiquitination (or Ubiquitylation) refers to the post-translational modification of a protein by the covalent attachment (via an isopeptide bond) of one or more ubiquitin monomers. Ubiquitin (originally, Ubiquitous Immunopoeitic Polypeptide) was first identified in 1975 as an 8.5 kDa protein of unknown function expressed universally in living cells.

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PCR from cDNA question

... very bright bands. for some transcription factors highly expressed at the same time, no bands at all. for a housekeeping gene in the species (ubiquitin), no bands. the regions of these gene i am amplifying are all 2kb, cycler conditions and PCR rxn mix followed factory recommended protocols. ...

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by vastgenome
Fri Jun 22, 2012 3:55 pm
Forum: Molecular Biology
Topic: PCR from cDNA question
Replies: 1
Views: 2570

What is non-canonical polyubiquitination?

i.e. usually is the ubiquitin bound to K48, while in your case it is K63

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by JackBean
Sat Dec 31, 2011 2:13 pm
Forum: Cell Biology
Topic: What is non-canonical polyubiquitination?
Replies: 3
Views: 1456

Re: Cell Question

... b) To decrease the activity of the product, you can use an enzyme inhibitor. c) To increase the degradation of the product, you can tag it with ubiquitin using ubiquitin ligase.

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by aptitude
Sat Sep 10, 2011 1:11 am
Forum: Cell Biology
Topic: Cell Question
Replies: 1
Views: 7805

Recombination in RNA viruses,Ruzic,Kovac

... of recombination between virus and host RNA. Journal of General Virology 72, 2591±2595. Meyers, G., Rumenapf, T. & Thiel, H. J. (1989). Ubiquitin in a togavirus. Nature 341, 491. Mindich, L. (1996). Heterologous recombination in the segmented dsRNA genome of bacteriophage u6. Seminars ...

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by anakovacevic
Sat Jun 12, 2010 8:28 pm
Forum: Cell Biology
Topic: Recombination in RNA viruses,Ruzic,Kovac
Replies: 2
Views: 30474

Proteins in Mitosos and the Cell Cycle :)

APC/C and SCF are the ubiquitin-protein ligases for the cell cycle. They themselves are not phosphorylated though. Sic1 is attached to S-phase cyclin/CDK, and when it becomes phosphorylated by the next phase cyclin/CDK, then it is marked ...

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by kolean
Mon Nov 30, 2009 3:10 pm
Forum: Cell Biology
Topic: Proteins in Mitosos and the Cell Cycle :)
Replies: 4
Views: 2880
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