Dictionary » U » Ubiquitin

Ubiquitin

Ubiquitin is a small regulatory protein that is ubiquitous in eukaryotes. Ubiquitination (or Ubiquitylation) refers to the post-translational modification of a protein by the covalent attachment (via an isopeptide bond) of one or more ubiquitin monomers. Ubiquitin (originally, Ubiquitous Immunopoeitic Polypeptide) was first identified in 1975 as an 8.5 kDa protein of unknown function expressed universally in living cells.


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Re: What does "deficient trafficking" means

... this. Based on your post, it sounds like the protein if interest is usually sent to the lysosome, but because it is misfolded it is tagged with a ubiquitin which leads to its degradation in the proteosome and its failure to reach the lysosome.

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by jonmoulton
Wed Jul 02, 2014 2:38 pm
 
Forum: Cell Biology
Topic: What does "deficient trafficking" means
Replies: 1
Views: 422

What does "deficient trafficking" means

I was reading a paper on disease mechanism where misfolding of a particular protein leads to its degradation by ubiquitin proteasome pathway and deficient trafficking to the lysosome. What does deficient trafficking means and overall what does this sentence means?? Kindly help ...

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by KSJ
Wed Jul 02, 2014 3:10 am
 
Forum: Cell Biology
Topic: What does "deficient trafficking" means
Replies: 1
Views: 422

PCR from cDNA question

... very bright bands. for some transcription factors highly expressed at the same time, no bands at all. for a housekeeping gene in the species (ubiquitin), no bands. the regions of these gene i am amplifying are all 2kb, cycler conditions and PCR rxn mix followed factory recommended protocols. ...

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by vastgenome
Fri Jun 22, 2012 3:55 pm
 
Forum: Molecular Biology
Topic: PCR from cDNA question
Replies: 1
Views: 3081

What is non-canonical polyubiquitination?

i.e. usually is the ubiquitin bound to K48, while in your case it is K63

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by JackBean
Sat Dec 31, 2011 2:13 pm
 
Forum: Cell Biology
Topic: What is non-canonical polyubiquitination?
Replies: 3
Views: 1613

Re: Cell Question

... b) To decrease the activity of the product, you can use an enzyme inhibitor. c) To increase the degradation of the product, you can tag it with ubiquitin using ubiquitin ligase.

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by aptitude
Sat Sep 10, 2011 1:11 am
 
Forum: Cell Biology
Topic: Cell Question
Replies: 1
Views: 7992
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