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Tumour suppressor

Cancer-critical genes are grouped into two broad classes, according to whether the cance risk arises from too much activity of the gene product, or too little. Genes of the first class, for which a gain-of-function mutation drives a cell toward cancer, are called proto-oncogenes; their mutant overactive forms are called oncogenes. Genes of the second class, for which a loss-of-function mutation creates the danger, are called tumour suppressor genes.

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LOH/somatic inactivation/biallelic inactivation?

... inactivation not always lead to loss of heterozygosity? e.g. "The tumour suppressor gene p53 is frequently inactivated in gastric carcinoma by loss of heterozygosity ...

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by Mike72
Thu Mar 01, 2012 4:04 pm
Forum: Genetics
Topic: LOH/somatic inactivation/biallelic inactivation?
Replies: 0
Views: 2082

Re: HEK293 cells fractionation

... The cell polarity regulator, human Scribble (hScrib), is a potential tumour suppressor whose loss is a frequent event in late-stage cancer development. hese results provide ...

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by harrygail87
Wed Dec 22, 2010 11:55 am
Forum: Cell Biology
Topic: HEK293 cells fractionation
Replies: 1
Views: 2414

What is cancer?(in genral)

... and the proteins involved in signalling any damage (such as p53-a tumour suppressor gene) means that abnormal cells are able to continue growing and dividing and accumulate ...

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by Katy_Bobbles
Tue Feb 19, 2008 9:00 pm
Forum: General Discussion
Topic: What is cancer?(in genral)
Replies: 8
Views: 7651

Cancer cells?

... to have accumulation of genetic mutations (i.e. loss of function of tumour suppressor genes and gain of function of oncogenes), which cause loss of control of the cell ...

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by Revenged
Tue Jun 26, 2007 11:30 pm
Forum: Human Biology
Topic: Cancer cells?
Replies: 5
Views: 3582

The Fiber Disease

... Kattoor , Prabha Balaram Nasopharyngeal carcinoma (NPC) is a unique tumour due to its aetiology, incidence pattern and its consistent association ... surface of epithelial cells. E-cadherin acts as an invasion/metastasis-suppressor gene, hence knowledge of the molecular mechanism that controls ...

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Fri Jan 12, 2007 11:04 pm
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 6266066

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