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Trypanosome

trypanosome

(Science: cell biology) A type of parasitic protozoan which can cause a number of serious diseases in people and domestic animals, including african sleeping sickness and leishmaniasis. The trypanosome is able to remain within a host's body for a very long time because it regularly changes the proteins (i.e. Antigens) on its outer surface, so that the host's immune system must constantly develop new antibodies in order to continue to recognise and destroy it. The trypanosome uses a large number of different genes which can be used in many combinations to come up with the different surface proteins. As a result, the host is never able to completely eliminate the trypanosome.

Origin: Gr. Soma = body


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Human immune system response to trypanosomes

Hey everyone, Would anyone happen to know the average time it takes for a healthy human's immune system to detect a trypanosome, before it changes its coat? I know it's quite a vague question, but by how much, if it's measurable, does the population usually decline before a new coat ...

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by Burnsey
Thu Apr 17, 2008 10:12 pm
 
Forum: Microbiology
Topic: Human immune system response to trypanosomes
Replies: 2
Views: 2893

The Fiber Disease

... forms of E. histolytica. It appears that the uptake of sialic acid in E. histolytica is developmentally regulated, as it also is in the African trypanosome (Engstler et al. 1993). This unique feature could represent an evolutionary linkage between the amitochondrial protist and African trypanosomes. ...

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by Nadas Moksha
Sun Dec 10, 2006 3:16 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 4989273

Does this could be a Spreading way of Chagas disease?

Chagas disease can be acquired through an insect vector, like trypanosome-carrying triatomine bugs... these bugs emerge at night to feed, a perfect time wen usually the host is in deep slumber... at the time of biting the bug also defecates :shock: , depositing ...

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by honee_v
Mon Oct 16, 2006 8:16 am
 
Forum: Microbiology
Topic: Does this could be a Spreading way of Chagas disease?
Replies: 5
Views: 4175

The Fiber Disease

... novo synthesized GPI precursors are attached to proteins post-translationally by the enzyme complex, GPI transamidase. TbGPI16, a component of the trypanosome transamidase, shares similarity with human PIG-T. Here, we show that TbGPI16 is the orthologue of PIG-T and an essential component of GPI ...

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by Nadas Moksha
Wed Oct 04, 2006 6:28 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 4989273

The Fiber Disease

In response to this last post: Opinion could be that you also have to mention Sanger and trypanosomes. tamtam ------------------- "Scientists led by the Wellcome Trust Sanger Institute have genetically modified the worm C. elegans to make human proteins called ...

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by tamtam
Sun Sep 17, 2006 9:50 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 4989273
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