Trisomy 21

... syndrome is often referred to as familial Down syndrome. It is the cause of 2–3% of observed cases of Down syndrome. 95% of the observed cases of Trisomy 21 is anueploidy caused by meiotic nondisjunction events in the parental gametes (88% in the female gamete, and 7% in the male gamete).

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hey kolean, isnt trisomy a result of anueploidy and not really of translocation? by the way to OP leukemia is a interesting concept to model knowledge on translocation, I would reccomened you look it up!

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... But if it is in meiosis, then the whole genome of the organism is affected by the translocation mutation, such as Down Syndrome/Trisomy 21(http://en.wikipedia.org/wiki/Down_syndrome).

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sure it can. Trisomy X is a well documented disease. Some types of Kinefelter syndrome have a karyotype of XXXY or even XXXXY.

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... are numbered according to size, plus the X and Y chromosomes. We often arrange and number the chromosomes from other species differently. Trisomy is when there is a third copy of one of the chromosomes. For example, Down's syndrome is caused by the presence of an extra copy of chromosome ...

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