Triplet repeat expansion disorder

Definition

noun, plural: trinucleotide repeat disorders

Any of a set of genetic disorders caused by three nucleotide repeats exceeding the stable threshold and expanding in successive generations (thus resulting in a non-Mendelian inheritance pattern).


Supplement

Most of them exhibit neurological or cognitive symptoms. Fragile X syndrome, Huntington disease, myotonic dystrophy, and Machado-Joseph disease are examples.


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