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triosephosphate isomerase

(Science: biochemistry, enzyme) An isomerizing enzyme that during glycolysis, catalyses the reversible interconversion of d-glyceraldehyde 3-phosphate to dihydroxyacetone phosphate and viceversa. A reaction of importance in glycolysis and gluconeogenesis.

A deficiency in humans causes congenital nonspherocytic haemolytic anaemia and severe neurological deficits.

Synonym: phosphotriose isomerase.

chemical name: D-glyceraldehyde-3-phosphate ketol isomerase

registry number: EC 5.3.1.1