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Tricarboxylic acid cycle

Definition

noun

(1) A cycle of reactions catalyzed by enzymes in which pyruvate derived from nutrients and converted to Acetyl Coenzyme A is completely oxidized and broken down into carbon dioxide and water to produce high-energy phosphate compounds, which are the source of cellular energy.

(2) One of the major metabolic pathways of cellular respiration, and involves a cyclic series of enzymatic reactions by which pyruvate converted into Acetyl Coenzyme A is completely oxidized to CO2 and hydrogen is removed from the carbon molecules, transferring the hydrogen atoms and electrons to electron-carrier molecules (e.g. NADH and FADH2) as well as the metabolic energy to high energy bonds (e.g. ATP).


Supplement

The tricarboxylic acid cycle is an alternative name for Krebs cycle, which was first described by Hans Adolf Krebs in 1937. It is called tricarboxylic acid cycle because the citric acid is both the first product and the final reactant, and it contains three carboxyl groups.


Also called: citric acid cycle, Krebs cycle.
See also: glycolysis, oxidative phosphorylation, cellular respiration.


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Please help!

1) Oxaloacetate is a compound (C4O5) in the tricarboxylic acid cycle, it is an isomer of Malate, after the action of Malate Dehydrogenase ...

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by billyfisher100
Sat Jan 21, 2012 1:13 pm
 
Forum: Cell Biology
Topic: Please help!
Replies: 10
Views: 5814

Re: TCA inhibitor

... electrons are from pyruvate being oxidized in tricarboxylic acid (TCA) cycle, while complex II is actually part of the TCA cycle being succinate ...

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by JackBean
Fri Jan 20, 2012 8:28 am
 
Forum: Cell Biology
Topic: TCA inhibitor
Replies: 3
Views: 6316

Re: Please help!

... no organelles). 2) Pyruvate will enter the tricarboxylic acid cycle, be catabolised by pyruvate dehydrogenase into either Acetyl ...

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by billyfisher100
Fri Jan 20, 2012 7:19 am
 
Forum: Cell Biology
Topic: Please help!
Replies: 10
Views: 5814

How does fat change to glucose?

... about plants, he probably means the glyoxylate cycle. http://en.wikipedia.org/wiki/Glyoxylate_cycle ... that's similar to the tricarboxylic acid cycle, but instead of decarboxylation steps, another ...

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by JackBean
Fri Mar 19, 2010 4:10 pm
 
Forum: Molecular Biology
Topic: How does fat change to glucose?
Replies: 6
Views: 3423

Creating a markscheme.

glycolysis? Tricarboxylic acid (TCA) cycle?

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by woolleyy
Mon Nov 26, 2007 10:42 am
 
Forum: Cell Biology
Topic: Creating a markscheme.
Replies: 4
Views: 2719
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