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Transforming growth factor

transforming growth factor

(Growth Factor) proteins secreted by transformed cells that can stimulate growth of normal cells.

Unfortunate misnomer, since they induce aspects of transformed phenotype, such as growth in semi solid agar, but do not actually transform.

Transforming growth factor alpha, 50 amino acid polypeptide originally isolated from viral transformed rodent cells, contains eGF like domain and binds to eGF receptor. Stimulates growth of microvascular endothelial cells, i.e. Is angiogenic.

Transforming growth factor beta a homodimer of two 112 chains, polypeptide is secreted by many different cell types, stimulates wound healing but in vitro is also a growth inhibitor for certain cell types. The transforming growth factor family includes many of the bone morphogenetic proteins.

Acronym: TGF


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Re: Which came first the DNA, RNA or protein

... RNA genes. A. TGF-beta acts as a transcription factor http://www.answers.com/topic/tgf-beta Transforming growth factor beta (TGF-beta) is a protein synthesized by skeletal ...

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by Dov Henis
Mon Mar 22, 2010 9:23 pm
 
Forum: Molecular Biology
Topic: Which came first the DNA, RNA or protein
Replies: 64
Views: 52653

The Fiber Disease

... implant, wherein the biological component is a growth factor or a source of growth factors. 2. The implant of ... factor is selected from the group consisting of a transforming growth factor-β, bone morphogenic protein, ...

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by Nadas Moksha
Fri Nov 17, 2006 12:59 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5429426

The Fiber Disease

... signalling pathways. Also: Connective tissue growth factor (CTGF) is a cysteine-rich peptide synthesized and secreted by fibroblastic cells after activation with transforming growth factor beta (TGF-ß) that acts as a downstream ...

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by London
Wed Jan 11, 2006 4:34 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5429426


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