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Transforming growth

transforming growth factor

(Science: growth factor) proteins secreted by transformed cells that can stimulate growth of normal cells.

Unfortunate misnomer, since they induce aspects of transformed phenotype, such as growth in semi solid agar, but do not actually transform.

Transforming growth factor alpha, 50 amino acid polypeptide originally isolated from viral transformed rodent cells, contains eGF like domain and binds to eGF receptor. Stimulates growth of microvascular endothelial cells, i.e. Is angiogenic.

Transforming growth factor beta a homodimer of two 112 chains, polypeptide is secreted by many different cell types, stimulates wound healing but in vitro is also a growth inhibitor for certain cell types. The transforming growth factor family includes many of the bone morphogenetic proteins.

Acronym: TGF


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Re:

... works. In another word, it keeps the "life cycles" from transforming to other forms of living such as migrating to another living ... of lives / the basic characteristics of lives remain unchanged. Birth, Growth, Aging & Death. Time is the thread to link all of them up and ...

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by kk23wong
Thu Sep 09, 2010 8:40 am
 
Forum: General Discussion
Topic: Structural Comparisons between Planets and the Cells
Replies: 8
Views: 9195

Re: Which came first the DNA, RNA or protein

... acts as a transcription factor http://www.answers.com/topic/tgf-beta Transforming growth factor beta (TGF-beta) is a protein synthesized by skeletal cells, found in most species, ...

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by Dov Henis
Mon Mar 22, 2010 9:23 pm
 
Forum: Molecular Biology
Topic: Which came first the DNA, RNA or protein
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Views: 52517

The Fiber Disease

... in association with the implant, wherein the biological component is a growth factor or a source of growth factors. 2. The implant of claim 1, wherein ... 1, wherein the growth factor is selected from the group consisting of a transforming growth factor-β, bone morphogenic protein, cartilage ...

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by Nadas Moksha
Fri Nov 17, 2006 12:59 am
 
Forum: Human Biology
Topic: The Fiber Disease
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Views: 5412247

The Fiber Disease

... ### Michigan State University has been advancing knowledge and transforming lives through innovative teaching, research and outreach for ... Infections in young pigs cause loss of appetite and slow stunted growth. Diagnostic Information: Characteristic eggs in faeces; worms at postmortem ...

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by Skytroll
Tue Sep 26, 2006 10:07 pm
 
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Unstable clones

... your mini-prep. Many "wacky" things can happen whe you're transforming plasmids... that's why you should always check several colonies. ... some hairpins. Even when I have a 'positive clone' and I start up a new growth from the glycerolstock, this positive clone will delete the hairpin ...

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by pjansen
Thu Apr 20, 2006 8:07 am
 
Forum: Molecular Biology
Topic: Unstable clones
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Views: 1962
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