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Transferrin

transferrin

(Science: haematology, protein) A protein that carries iron in the bloodstream (80 kD) found in mammalian serum, a beta globulin.

binds ferric iron with a Kass of around 21 at pH 7.4, 18.1 at pH 6.6. An important constituent of growth media.

Transferrin receptors on the cell surface bind transferrin as part of the transport route of iron into cells.

The percentage of transferrin that has iron bound to it is increased in situations of iron overdose and in the disease haemochromatosis. Serum transferrin is decreased in cases of protein deficiency.


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Active Transportation in the human body

... blood, it takes up the whole particle by receptor mediated endocytosis for apolipoproteins. 2. Iron travels in the blood bound to a protein named transferrin. when a cell needs iron it takes it up from the blood by receptor mediated endocytosis for transferrin. Regards, Andrew

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by MrMistery
Sun Aug 19, 2007 8:05 pm
 
Forum: Cell Biology
Topic: Active Transportation in the human body
Replies: 4
Views: 3098

Calculations

Kewl, thanks for pointing that out! Think I've got the answer to number 5 too. 5. There are 100,000 transferrin receptors, 200,000 are bound. We need equal concentrations of bound and unbound receptors, therefore 400,000 transferrin receptors. 400,000/ Avagadro 6.022*10^23 ...

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by hotlikefudge
Mon Dec 04, 2006 1:00 pm
 
Forum: Cell Biology
Topic: Calculations
Replies: 3
Views: 663

Calculations

... in pit to every 1 receptor on cell surface) 4. 10nM= 10*10^-9M (10 *10^-9) * Avagadro (6.022 *10^15) =6.022 * 10^15 - 200,000 (molecules of Transferrin needed) =6.002 *10^15. Thats all I've done so far. Do you know where this question originates from?

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by hotlikefudge
Sun Dec 03, 2006 11:41 pm
 
Forum: Cell Biology
Topic: Calculations
Replies: 3
Views: 663

Calculations

... a single coated pit is the same of that of a 100 nm diameter clathrin-coated vesicle that will be formed from it. If the cell surface has 100, 000 transferrin receptors and 70% are localised within coated pits, work out the following: 3) What is the relative concentration of transferrin receptors ...

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by sweety_girl
Fri Dec 01, 2006 1:35 pm
 
Forum: Cell Biology
Topic: Calculations
Replies: 3
Views: 663

Phagocytosis

... can get everything. An extracellular material called ligand is links to the receptor, forms a ligand-receptor complex. (examples of ligands: LDL, transferrin) The vesicle is covered with a protein membrane-like structure. Then taken into the cytosol. Then carried to the lysosome.

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by Poison
Fri Nov 18, 2005 12:01 pm
 
Forum: Cell Biology
Topic: Phagocytosis
Replies: 15
Views: 2249
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