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Transferrin

transferrin

(Science: haematology, protein) A protein that carries iron in the bloodstream (80 kD) found in mammalian serum, a beta globulin.

binds ferric iron with a Kass of around 21 at pH 7.4, 18.1 at pH 6.6. An important constituent of growth media.

Transferrin receptors on the cell surface bind transferrin as part of the transport route of iron into cells.

The percentage of transferrin that has iron bound to it is increased in situations of iron overdose and in the disease haemochromatosis. Serum transferrin is decreased in cases of protein deficiency.


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Biology Calculation-is this correct?

Hey, for the number of transferrin receptors in each coated pit I've got: 100 000 receptors, 70% localised within the coated pits so: 100 000 x 70% = 70 000 receptors in the coated pits. There are 70 000 receptors and 2165 coated pits ...

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by Kezzer
Thu Dec 02, 2010 10:19 pm
 
Forum: Molecular Biology
Topic: Biology Calculation-is this correct?
Replies: 5
Views: 3043

Re: Biology Calculation-is this correct?

... the end because they only account for 2% of the total suface area which is 68micrometers squared. The next question is to then calculate how many transferrin receptors there are in each coated pit, but I just can't get my head round how to do that.

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by Kezzer
Tue Nov 30, 2010 5:16 pm
 
Forum: Molecular Biology
Topic: Biology Calculation-is this correct?
Replies: 5
Views: 3043

Biology Calculation-is this correct?

... a single coated pit is the same of that of a 100nm diameter clathrin coated vesicle that will be formed from it. If the cell surface has 100,000 transferrin receptors, around 70% are localised within coated pits: work out how many coated pits there are. Ive got: 3,400 * 2% = 68 micrometers(squared) ...

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by Kezzer
Sun Nov 28, 2010 4:49 pm
 
Forum: Molecular Biology
Topic: Biology Calculation-is this correct?
Replies: 5
Views: 3043

GMP compatible reagents

... elements, L-glutamine and 30 mM HEPES 3. ITS+1 Liquid Media Supplement (100Å~) - Contains 1.0 mg/ml insulin from bovine pancreas, 0.55 mg/ml human transferrin (substantially iron-free), 0.5 É g/ml sodium selenite, 50 mg/ml bovine serum albumin and 470 É g/ml linoleic acid. 4. L-ascorbic acid. Please ...

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by tinghuay
Wed Oct 27, 2010 2:33 pm
 
Forum: Cell Biology
Topic: GMP compatible reagents
Replies: 0
Views: 2165

Active Transportation in the human body

... blood, it takes up the whole particle by receptor mediated endocytosis for apolipoproteins. 2. Iron travels in the blood bound to a protein named transferrin. when a cell needs iron it takes it up from the blood by receptor mediated endocytosis for transferrin. Regards, Andrew

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by MrMistery
Sun Aug 19, 2007 8:05 pm
 
Forum: Cell Biology
Topic: Active Transportation in the human body
Replies: 4
Views: 11859
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