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Transcriptional silencing

transcriptional silencing

(Science: molecular biology) mechanism of transcriptional control where dNA is bundled into heterochromatin in order to make it permanently inaccessible for future transcription.

Effectively, this allows for memory in the determination of cell fate in developing organisms. In drosophila, homeotic genes are silenced by members of the polycomb group of genes.

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imprinted genes inactivation

... is, what "marked" means - are these marks direct cause of transcriptional inactivity of the gene or are they serving as a platform for silencing machinery in the embryo?

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by McFly
Thu Jan 26, 2012 2:37 pm
Forum: Genetics
Topic: imprinted genes inactivation
Replies: 5
Views: 1913

Re: Issues of EST in whole genome gene discovery

... unfeasible, then you need would need a more sensitive assay, eg. a gene silencing experiment with an assay that you can detect. Finally, besides gene discovery, EST can be used to study post transcriptional control on a genomic level, which have been shown very successful, ...

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by merv
Sun Oct 02, 2011 7:46 pm
Forum: Bioinformatics
Topic: Issues of EST in whole genome gene discovery
Replies: 6
Views: 12568

Re: RNA interference

... grab the mature miRNA and load it into the RISC (RNA-induced silencing complex) with the Ago proteins grabbing it. The mature 20-22 nts ... and can be placed into a different Ago and into the RITS (RNA-induced transcriptional Silencing) complex. Usually the siRNAs bind to the mRNA in ...

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by kolean
Mon Apr 12, 2010 2:14 am
Forum: Molecular Biology
Topic: RNA interference
Replies: 3
Views: 4717

RNA interference

... interfering RNA, knowing that both are involved in rna-mediated post-transcriptional gene silencing. and if possible, can we discuss the mech each of them uses.. i dint unstan fron ...

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by Jasmine0507
Sun Apr 11, 2010 8:45 pm
Forum: Molecular Biology
Topic: RNA interference
Replies: 3
Views: 4717

What is transgene silencing??

What are transgene silencing, disruption of endogenous genes and the transcriptional activation of neighboring genes? Plz help! thnx :)

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by Agrin1369
Wed Nov 18, 2009 1:56 am
Forum: Genetics
Topic: What is transgene silencing??
Replies: 1
Views: 2923
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