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Transcription factor

transcription factor

(Science: molecular biology) protein required for recognition by rNA polymerases of specific stimulatory sequences in eukaryotic genes.

Several are known that activate transcription by rNA polymerase II when bound to upstream promoters.

transcription of the 5S rNA gene in xenopus by rNA polymerase III is dependent on a 40 kD protein TFIIIA that binds to a regulatory site in the centre of the gene and was the first protein found to exhibit the metal binding domains known as zinc fingers.

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mRNA vs. cell reporter assay

... GFP reporter cell line that drives GFP expression upon activation of a transcription factor. In theory, I can study transcription factor activation via the GFP signal, or by measuring ...

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by aguy
Mon Jul 07, 2014 2:50 am
Forum: Cell Biology
Topic: mRNA vs. cell reporter assay
Replies: 0
Views: 237

Sigma Factor Functions in Bacterial vs. Eukaryotes

PLEASE HELP! BIOCHEMISTRY HOMEWORK Sigma factor performs four important functions, each required before transcription can begin at a core promoter in bacteria. A) List the four functions. B) Name the transcription ...

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by sabrina9
Sat Nov 02, 2013 9:49 pm
Forum: Molecular Biology
Topic: Sigma Factor Functions in Bacterial vs. Eukaryotes
Replies: 0
Views: 986

Transcrption factor-promoter (cis-element) interaction

I want to transfect my cells with a vector for promoter activity analaysis, I need to detect the binding effeciency of some transcription factors to the promoter, what technique should I use? I have read about ChIP but don't know how to design and perform this experiment practically ...

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by roniadam
Sun Aug 11, 2013 2:43 am
Forum: Molecular Biology
Topic: Transcrption factor-promoter (cis-element) interaction
Replies: 3
Views: 1199

Bio Research Paper Writing

... of the immune system in senescence (DNA-Damage-Response np). One factor is the loss of the CD28 marker; when CD28 isn’t expressed, antigen-presenting ... with lymphomas and carcinomas by modulating EBNA3A, EBNA3B, and EBNA3C (transcription regulators) that are responsible for transforming B cells ...

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by NathanielZhu
Thu Apr 04, 2013 2:25 am
Forum: General Discussion
Topic: Bio Research Paper Writing
Replies: 1
Views: 11900

Comprehensive List of TFBSs database from ChIP-Seq data

Comprehensive List of transcription factor binding sites (TFBSs) databases based on ChIP-seq data as follows: (1) ChEA : transcription factor ...

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by rnaworld2110
Fri Feb 15, 2013 6:59 am
Forum: Molecular Biology
Topic: Comprehensive List of TFBSs database from ChIP-Seq data
Replies: 0
Views: 1991
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