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Transcription

Definition

noun

It is the process of transcribing or making a copy of genetic information stored in a DNA strand into a complementary strand of RNA (messenger RNA or mRNA) with the aid of RNA polymerases.


Supplement

Although RNA polymerase traverses the DNA template strand from 3' → 5', the coding (non-template) strand is usually used as the reference point. Hence, the process proceeds in the 5' → 3' direction, like in DNA replication. However, unlike DNA replication, transcription does not need a primer to start and it uses base pairing to create an RNA copy containing uracil instead of thymine.

In prokaryotes transcription occurs in the cytoplasm whereas in eukaryotes it takes place primarily in the nucleus before the mRNA is transported into the cytoplasm for translation or for protein synthesis.


Related forms: transcriptional (adjective), transcriptionally (adverb), transcriptiive (adjective), transcribe (verb).
Related phrases: transcription factor, reverse transcription.

See also: RNA, protein synthesis.


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... internal and external signals to stop dividing. CMV and EBV is associated with lymphomas and carcinomas by modulating EBNA3A, EBNA3B, and EBNA3C (transcription regulators) that are responsible for transforming B cells into lymphoblastoid cells; in individuals with EBV, these oncogenes are upregulated ...

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RNA

check out transcription. If you'll have more specific questions, feel free to come back and ask in a new thread.

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PHF20 is a transcription factor that seems to be unique to the production of p53. (see http://www.sciencedaily.com/releases/2012/08/120824082534.htm ). The wrap53 gene is produces mRNA that is antisense to p53 mRNA(see http:// ...

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RT-PCR

... different. Yes, for qPCR one should have only short amplicons, but I don't see reason why should you amplify only short pieces during reverse transcription.

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by JackBean
Mon Jan 28, 2013 1:49 pm
 
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