A method for measuring or monitoring the degree and type of neuromuscular blockade by measuring the twitch or muscle response to a train of four consecutive stimuli applied to a peripheral motor nerve at 2 Hz each for 2 seconds at brief intervals (e.g. 10 seconds), then taking the ratio of the fourth response to the first response.
This method is a reliable test for monitoring neuromuscular blockade, as well as a basis for delivering a dose of a neuromuscular blocking agent when inducing a temporary paralysis. The most common sites for this test are the ulnar nerves of the arm and the superficial peroneal nerve of the foot.
Abbreviation: TOF stimulus