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thyroid stimulating antibody

(Science: endocrinology, immunology) long acting thyroid stimulator is an autoantibody found in many cases of primary thyrotoxicosis which causes hyperplasia of the thyroid by undetermined mechanisms. Human thyroid stimulating immunoglobulin is a different antibody found in all or nearly all cases of primary thyrotoxicosis and may act by binding to the thyrotropin (tSH) receptor site, causing increased synthesis of thyroglobulin.