Thymus

In a nutshell, T cells (or their progenitors, rather) first divide actively and start to differentiate in the bone marrow, then migrate to thymus where they continue to mature (including T cell receptor assembly, psoitive and negative selection, double CD4+/CD8+ phase etc.) and then move to ...

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Well, you almost got it :) RTEs already express CD4 or CD8 marker (all T cells leaving the thymus are "single positive" CD4+ or CD8+ cells, although these include a small subset of CD4+ regulatory T cells). However, there are some other differences that separate ...

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Thanks for the explanation biohazard. I think i've got it now: The T cells are produced in the thymus as naive CD4+ and CD8+ cells and then recognise the antigen in the lymph nodes (mainly) but recently there have been RTE's discovered which are not yet CD4 or CD8 positive ...

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... For CD4+ cells, for example, there are so-called recent thymic emigrants (RTE, yeah sounds stupid I know :P), T cells that have emerged from the thymus after their T cell receptor has been deemed appropriate (e.g. it does not recognize self molecules with high affinity, but recognizes foreign ...

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So after they have been activated in the lymph nodes they travel to the thymus where they differentiate and then migrate to infected tissue If anyone knows of a source which provides a good overview of this please let me know. I dont want to sound lazy because ...

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