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Thymus

thymus

(Science: anatomy) The lymphoid organ in which t lymphocytes are educated, mature and multiply. It is composed of stroma (thymic epithelium) and lymphocytes, almost entirely of the t-cell lineage. In mammals the thymus is just anterior to the heart within the rib cage, in other vertebrates in rather undefined regions of the neck or within the gill chamber in teleost fish. The thymus regresses as the animal matures.


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What does this mean??? Please help

... .2 are described in Shiku et al . (ref. 10, Table III) . The Ly antisera we used, diluted 1 :10, were absorbed once with 120 x 10 8 syngeneic thymus + LNC/ml to remove autoantibody . Complement (C)-Dependent Cytotoxicity Assay . 10-40 x 10 8 cells/ml ("Cr-labeled ; 30 min, 100 juCi/ml) ...

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by speakers2
Sun Oct 16, 2011 1:06 am
 
Forum: General Discussion
Topic: What does this mean??? Please help
Replies: 0
Views: 975

Re: Cytokine - Receptor concepts

... are usually defined by the structure of the receptor, and with T cells the arrangement of alpha and beta chains whilst they mature in the thymus, therefore they will need very little of one cytokine to have an effect and a much higher concentration of another. This affinity regulation ...

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by Nataly56
Thu Jul 14, 2011 7:47 am
 
Forum: Cell Biology
Topic: Cytokine - Receptor concepts
Replies: 7
Views: 10376

Re: Re:

So even if a virus could invade the thymus and thus eliminate the T cells specific for it, the somewhat loose nature of TCR binding would allow other T cells with near-identical TCRs to recognize the virus. Interesting... But if this loose ...

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by biohazard
Wed Jun 29, 2011 6:43 am
 
Forum: Human Biology
Topic: How does negative selection in the thymus get around viral a
Replies: 3
Views: 4410

Re:

So even if a virus could invade the thymus and thus eliminate the T cells specific for it, the somewhat loose nature of TCR binding would allow other T cells with near-identical TCRs to recognize the virus. Interesting... But if this loose ...

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by micro999
Tue Jun 28, 2011 4:28 pm
 
Forum: Human Biology
Topic: How does negative selection in the thymus get around viral a
Replies: 3
Views: 4410

How does negative selection in the thymus get around viral a

... said that many clonal TCRs can recognize several epitopes with varying affinities - with varying outcomes. So even if a virus could invade the thymus and thus eliminate the T cells specific for it, the somewhat loose nature of TCR binding would allow other T cells with near-identical TCRs to ...

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by biohazard
Tue Jun 28, 2011 6:52 am
 
Forum: Human Biology
Topic: How does negative selection in the thymus get around viral a
Replies: 3
Views: 4410
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