Dictionary » T » Thrombin



(Science: enzyme) protease (34 kD) generated in blood clotting that acts on fibrinogen to produce fibrin. Consists of two chains, A and B, linked by a disulphide bond. B chain has sequence homology with pancreatic serine proteases: cleaves at arg gly.

Thrombin is produced from prothrombin by the action either of the extrinsic system (tissue factor _ phospholipid) or, more importantly, the intrinsic system (contact of blood with a foreign surface or connective tissue). Both extrinsic and intrinsic systems activate plasma factor X to form factor Xa which then, in conjunction with phospholipid (tissue derived or platelet factor 3) and factor V, catalyses the conversion.

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Connection between opioid receptors and fatty acid receptors

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by mhein
Tue Jul 10, 2012 2:00 pm
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thrombin cleavage

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by higherme
Thu Apr 03, 2008 10:53 pm
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by blcr11
Thu Sep 06, 2007 1:17 am
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... in great detail. A very simple explanation we had in our bio lecture was that cells at the site of injury release clotting factors that convert prothrombin to thrombin, which in turn converts fibrinogen to fibrin, which helps platelets to form a clot.

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by Jammerz
Tue Apr 24, 2007 4:48 am
Forum: Cell Biology
Replies: 5
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pls help- URGENT!!!

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by unscientific
Tue Mar 06, 2007 2:06 pm
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Topic: pls help- URGENT!!!
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