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TGF --> transforming growth factor

(Science: growth factor) proteins secreted by transformed cells that can stimulate growth of normal cells.

Unfortunate misnomer, since they induce aspects of transformed phenotype, such as growth in semi solid agar, but do not actually transform.

Transforming growth factor alpha, 50 amino acid polypeptide originally isolated from viral transformed rodent cells, contains eGF like domain and binds to eGF receptor. Stimulates growth of microvascular endothelial cells, i.e. Is angiogenic.

Transforming growth factor beta a homodimer of two 112 chains, polypeptide is secreted by many different cell types, stimulates wound healing but in vitro is also a growth inhibitor for certain cell types. The transforming growth factor family includes many of the bone morphogenetic proteins.

Acronym: TGF

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Bone remodelling

... glucocorticoids, thyroid hormones, and sex hormones. Factors such as insulin-like growth factors (IGFs), prostaglandins, tumor growth factor-beta (TGF-beta), bone morphogenetic proteins (BMP), and cytokines are involved as well. As far as local regulation of bone remodeling is concerned, a large ...

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by matrix23
Tue Aug 02, 2011 9:08 am
Forum: Physiology
Topic: Bone remodelling
Replies: 11
Views: 33550

URGENT: Need a paper

Hi, I need to read this paper for my upcoming qualifying exam and I can't find it anywhere! E.S. Kim, M.S. Kim and A. Moon, TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells, Int. J. Oncol. 25 (2004), pp. ...

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by mutant11
Sat May 14, 2011 7:44 pm
Forum: PDF & Doc Files
Topic: URGENT: Need a paper
Replies: 2
Views: 2455

Re: Which came first the DNA, RNA or protein

... Transcription Factors, Made By RNA Genes From DNA Templates Made By The Genes, Transcription Factors That Activate Genes, The RNA genes. A. TGF-beta acts as a transcription factor http://www.answers.com/topic/tgf-beta Transforming growth factor beta (TGF-beta) is a protein synthesized by ...

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by Dov Henis
Mon Mar 22, 2010 9:23 pm
Forum: Molecular Biology
Topic: Which came first the DNA, RNA or protein
Replies: 64
Views: 53136

Webbed toes

... that lead to this pathway malfunction, or if there's any cross over between them and anti-oncogenic apoptosis pathways. Just FYI, BMP activates a TGF{beta} Receptor Ser/Thr Kinase pathway leading to activation of Smad 1,5 which dimerizes with Smad 4 then translocates to the nuclease where it acts ...

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by dae
Mon May 05, 2008 8:10 am
Forum: Cell Biology
Topic: Webbed toes
Replies: 3
Views: 5258

growth of cancer cells

Every cell, including cancer cell, needs nutrients to support their life. In vivo, they release some cytokin e.g. TGF (tumour growth factor) and TAF (tumour angiogenesis factor) to facilitate new blood vessels which bring nutrients by the plasma. In vivo, this condition never happens, ...

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by Dr.Stein
Fri Aug 25, 2006 4:07 am
Forum: Human Biology
Topic: growth of cancer cells
Replies: 3
Views: 1576
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