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Tetracyclines

tetracyclines

Closely congeneric derivatives of the polycyclic naphthacenecarboxamide. (gilman et al., goodman and gilman's the pharmacological basis of therapeutics, 8th ed, p1117)


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... evidence shows is that, it is the direct clinical intervention that induces the acquisition of these natural occurring mobile genetic elements in tetracyclines that produces the resistance. I also went on to state Even if a mutation occurs in the ribosome that may provide an advantage to the bacterium, ...

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... Page 243 has this to say. Resistance to tetracycline may be mediated by one of three different mechanism: (I) an energy-dependant efflux of tetracyclines carried out by by transmembrane spanning proteins which results in reduction of the concentration of tetracycline in the cytosol: (II) ...

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