Tetanus toxin

tetanus toxin

(Science: protein) neurotoxin released by clostridium tetani, becomes active when peptide cleaved proteolytically to heavy (100 kD) and light (50 kD) chains held together by disulphide bond. Heavy chain binds to disialogangliosides (GD2 and GD1b) and part of the peptide (the amino terminal B fragment) forms a pore: light chain is a zinc endopeptidase that specifically attacks synaptobrevin, to block neurotransmitters.

See: botulinum toxin

Retrieved from "http://www.biology-online.org/bodict/index.php?title=Tetanus_toxin&oldid=27737"
First | Previous (Tetanus shot) | Next (Tetanus vaccine) | Last
Please contribute to this project, if you have more information about this term feel free to edit this page.