Tachykinin receptor 1
Tachykinin receptor 1 contains 407 amino acid residues with molecular weight of 58.000 and is made up of seven hydrophobic transmembrane domains with three intracellular and extracellular loops. This loops has a functional sites including two cysteine amino acids for disulfide bridge which is responsible for the connection and interaction with G-proteins.
Tachykinin receptor 1 is involved in the mediation of phosphatidyl inositol metabolism of substance P wherein binding to this, has been associated with the transmission of stress signals and pain as well as the contraction of the smooth muscle and inflammation. It is also implicated in rheumatoid, asthma, arthritis and gastrointestinal disorders where its antagonist has been involved in migraine and psychiatric disorder.
Tachykinin receptor 1 is present in vascular endothelial cells, muscle, neurons, brainstem, genitourinary tract, gastrointestinal tract, pulmonary tissues, thyroid gland and different immune cells. It also intervene in neuropeptide signaling, as a mediator in baroreflex transmission for blood pressure regulation and play a task in pain sensitivity.
Gene name: TACR1
Protein name: Substance-P receptor