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TCR

Definition

noun

(immunology) An abbreviation for T cell receptor, an antigen-recognizing receptor in the surface of T cell, which is involved in animal's immune function.


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See also: immune system

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Re:

... first between the killer and natural killer cells first. T-lymphocytes are can be distinguished from NK (and B-cells) as it is having a special TCR (T-cell receptor) Important functions: T-cell : capable to recognize peptide antigen presented by MHC I. It is a part of adaptive immune system. ...

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by greatmicrobiologist
Thu Aug 25, 2011 10:23 am
 
Forum: Cell Biology
Topic: Killer Cells vs. Cytotoxic Cells
Replies: 9
Views: 30555

Re: Re:

So even if a virus could invade the thymus and thus eliminate the T cells specific for it, the somewhat loose nature of TCR binding would allow other T cells with near-identical TCRs to recognize the virus. Interesting... But if this loose nature of TCR binding allows T cell recognition ...

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by biohazard
Wed Jun 29, 2011 6:43 am
 
Forum: Human Biology
Topic: How does negative selection in the thymus get around viral a
Replies: 3
Views: 5925

Re:

So even if a virus could invade the thymus and thus eliminate the T cells specific for it, the somewhat loose nature of TCR binding would allow other T cells with near-identical TCRs to recognize the virus. Interesting... But if this loose nature of TCR binding allows T cell recognition ...

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by micro999
Tue Jun 28, 2011 4:28 pm
 
Forum: Human Biology
Topic: How does negative selection in the thymus get around viral a
Replies: 3
Views: 5925

How does negative selection in the thymus get around viral a

... properties of T cells responding to the T cell receptor signals. Although the article focused mainly on autoimmunity, they said that many clonal TCRs can recognize several epitopes with varying affinities - with varying outcomes. So even if a virus could invade the thymus and thus eliminate the ...

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by biohazard
Tue Jun 28, 2011 6:52 am
 
Forum: Human Biology
Topic: How does negative selection in the thymus get around viral a
Replies: 3
Views: 5925

Immune System

... a single unique surface receptor. - CD4 and CD8 are surface glycoproteins, so not really similar to antibodies. They act as co-receptors for the TCR along with MHC, the primary function of which is to hold the two cells close together during recognition.

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by Babybel56
Tue May 10, 2011 7:05 pm
 
Forum: Human Biology
Topic: Immune System
Replies: 4
Views: 5703
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