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Synergy

Definition

noun

The interaction of biological structures or substances that produce an overall effect greater than the sum of individual effects of any of them


Supplement

Synergism occurs when different entities working together and enhance the effect to an extent that cannot be produced singly. Synergism is used pharmacologically to enhance the efficacy of a set of drugs.


Word origin: Greek syn-ergos (working together)

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My “Eureka” moment. A cure for cancer.

Synergy My approach offers a better cure by using various drugs and methods in a synergistic way, each making up for the short-fall of the other. I'd like to review the drawbacks of existing anti-cancer methods and drugs ...

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by PeterDow
Sat Oct 26, 2013 2:33 pm
 
Forum: Human Biology
Topic: My “Eureka” moment. A cure for cancer.
Replies: 9
Views: 10824

Re: splicing MO vs translation MO

... advantage to the two-nonoverlapping-oligo experiment. This is that once you have the pair of oligos, you can do coinjections both to test for synergy and to exploit synergy in order to conserve oligo. So, to sum up and answer your question directly, I don't suggest you buy another 5-mispair. ...

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by jonmoulton
Mon Aug 25, 2008 5:47 pm
 
Forum: Molecular Biology
Topic: splicing MO vs translation MO
Replies: 14
Views: 11552

Re: splicing MO vs translation MO

... of the targeted gene and not an off-target RNA. Only if the off-target RNA had sites where both of the oligos could bind would you see the dose-synergy effect on an off-target RNA; while there is some probability of both targets being present in the off-target RNA if the off-target RNA is closely ...

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by jonmoulton
Wed Aug 20, 2008 4:57 pm
 
Forum: Molecular Biology
Topic: splicing MO vs translation MO
Replies: 14
Views: 11552

Re: splicing MO vs translation MO

... case, the effect is caused not by the Morpholino directly but by the loss of the target protein, so a reduced dose used when producing an oligo-synergy knockdown won't solve the problem: it is the knockdown, not the oligo, that triggers the p53 pathway. In this case you need to knock down p53 ...

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by jonmoulton
Tue Aug 19, 2008 4:22 pm
 
Forum: Molecular Biology
Topic: splicing MO vs translation MO
Replies: 14
Views: 11552

Re: splicing MO vs translation MO

... the Morpholinos on the targeted RNA and not an off-target RNA. The two nonoverlapping oligo can be coinjected in subsequent experiments and due to synergy they can usually be used at lower doses, conserving oligo. The first exon-intron oligo (e1i1) is most likely to cause insertion of intron 1 ...

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by jonmoulton
Mon Aug 18, 2008 6:19 pm
 
Forum: Molecular Biology
Topic: splicing MO vs translation MO
Replies: 14
Views: 11552
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