Dictionary » S » Syndecan



(Science: protein) An integral membrane proteoglycan (250-300 kD) associated largely with epithelial cells.

The core protein of 294 amino acids has an extracellular domain of 235 amino acids and a single transmembrane domain of 25 amino acids. The extracellular domain has up to three heparan sulphate and two chondroitin or dermatan sulphate chains plus an N linked oligosaccharide.

The heparan sulphate chains bind to several proteins of the extracellular matrix, including collagens, fibronectin and tenascin. The cytoplasmic domain is thought to interact with actin filaments. Its name is derived from the greek syndein, to bind together.

Please contribute to this project, if you have more information about this term feel free to edit this page

This page was last modified 21:16, 3 October 2005. This page has been accessed 1,173 times. 
What links here | Related changes | Permanent link