Surrogate marker

Definition

noun

(1) A measure of the biological activity inside the body that indicates the effect of treatment on the state of disease.

(2) A laboratory biomarker that measures the effect of a treatment to indicate, reflect or substitute a clinical endpoint.


Supplement

In clinical or laboratory experiments, surrogate markers are used when a clinical endpoint is undesired or unethical to wait for (e.g. death) or when there are limited number of cases.

An example is CD4 cell counts as a surrogate marker for death from HIV infection.


Also called: surrogate endpoint

See also: clinical endpoint

Retrieved from "http://www.biology-online.org/bodict/index.php?title=Surrogate_marker&oldid=96739"
First | Previous (Surrogate endpoint) | Next (Surrogate mother) | Last
Please contribute to this project, if you have more information about this term feel free to edit this page.