Dictionary » S » Surrogate marker

Surrogate marker

Definition

noun

(1) A measure of the biological activity inside the body that indicates the effect of treatment on the state of disease.

(2) A laboratory biomarker that measures the effect of a treatment to indicate, reflect or substitute a clinical endpoint.


Supplement

In clinical or laboratory experiments, surrogate markers are used when a clinical endpoint is undesired or unethical to wait for (e.g. death) or when there are limited number of cases.

An example is CD4 cell counts as a surrogate marker for death from HIV infection.


Also called: surrogate endpoint

See also: clinical endpoint


Please contribute to this project, if you have more information about this term feel free to edit this page



Results from our forum


The Fiber Disease

... establishing a taxon (336) or for suggesting that a single molecular marker can serve to reveal phylogenetic relationships of bacteria (162).eukaryotes ... assays than in in vitro assays (210). In this context, construction of surrogate host cells for in vivo drug screening is an interesting development. ...

See entire post
by tamtam
Thu Jan 04, 2007 2:46 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5478552

The Fiber Disease

... ____________________________________ Enzymatic degradation of prion surrogate proteins, Jason Shih, Poultry Science, North Carolina State University, ... normal nervous tissue in a pilot-scale pressure cooker and serve as a marker for prion degradability The rest of story can be found on page 53 ...

See entire post
by London
Sun Nov 26, 2006 3:11 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5478552

The Fiber Disease

... become immensely important in electrochemical research as a potential surrogate material for mercury.The combination of a preconcentration step ... the tobacco feedback -insensitive ASA2 gene can be used as a selectable marker for transformation"

See entire post
by Nadas Moksha
Sat Aug 19, 2006 10:50 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5478552

Cancer Vaccines: Unanswered Questions

... the next 5 years’. It seemed appropriate that we were voting about a surrogate end-point regarding future success of cancer vaccines – a vote ... in the USA. Practically, Holloway urged that even if the surrogate markers do not currently correlate well with clinical outcomes, we should ...

See entire post
by conecticut
Mon Aug 01, 2005 1:45 pm
 
Forum: Genetics
Topic: Cancer Vaccines: Unanswered Questions
Replies: 3
Views: 7678


This page was last modified 01:21, 29 August 2009. This page has been accessed 18,912 times. 
What links here | Related changes | Permanent link