Dictionary » S » Suppressors


suppressor-sensitive mutant

A conditionally lethal, host range, bacteriophage mutant that produces nonsense codons and can replicate only in a host bacterium able to translate the nonsense codon; the mutation's effects are lethal (i.e., prevent replication of the virus) in a bacterium without such a suppressor mechanism.

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Re: Tissue cells and cancers.

... E2F required for expression of the S-phase genes"). p53 also acts at the G2/M transition stage. Both RB and p53 genes are (therefore) tumour suppressors. If their gene products are inactivated (by phosphorylation, eg, RB protein phosphoryalated by CDK - cyclin dependent kinase), then the ...

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by Julie5
Tue Sep 21, 2010 9:21 am
Forum: General Discussion
Topic: Tissue cells and cancers.
Replies: 4
Views: 9446

human papilloma virus

... HPV (there are only 9-12 or so) and look at the function for each. I think there are two viral proteins that inhibit two different cellular tumor suppressors, p53 and retinoblastoma. Epithelial stem cells infected with HPV will not enter the lytic cycle (although their differentiated descendants ...

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by snowcapk
Sat Apr 19, 2008 9:31 am
Forum: Cell Biology
Topic: human papilloma virus
Replies: 2
Views: 2565

Re: alternative splicing

... by changes in the concentrations of splice regulatory proteins that bind to regulatory target sites on the pre-mRNA, such as intronic splice suppressors or exonic splice enhancers. The activity of the proteins that bind these sites can be regulated physiologically. Alternative transcripts ...

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by jonmoulton
Fri Apr 18, 2008 3:34 pm
Forum: Molecular Biology
Topic: alternative splicing
Replies: 1
Views: 1720

sui- suppressor selection

how would i go about selecting for suppressors of the Sui(-) phenotype in a sui2 yeast strain?

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by yohannus
Wed Oct 31, 2007 6:26 pm
Forum: Molecular Biology
Topic: sui- suppressor selection
Replies: 0
Views: 844

Cell motility/invasiveness assay?

... any one has had any experience with them please let me know! Also, would anyone happen to know of any tissue culture assays for identifying tumor suppressors or oncogenes? Thanks for your time!

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by Newbie
Wed Mar 07, 2007 6:37 pm
Forum: Cell Biology
Topic: Cell motility/invasiveness assay?
Replies: 2
Views: 1675
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