Suppressor t-cell

... or separate? If you're heterozygous, does somatic/biallelic inactivation not always lead to loss of heterozygosity? e.g. "The tumour suppressor gene p53 is frequently inactivated in gastric carcinoma by loss of heterozygosity (LOH), missense mutations and frame shift deletions" ...

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... to cancer biology class. The BRCA1 gene was discussed and it was mentioned that it is causative (?) for breast cancer. However, it is a tumor suppressor of sorts and is present in all the cells. Then what happens when it comes to other cells? Why does a defect in this particular gene does ...

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There is some overlap - a tumor suppressor could be a proto-oncogene. But not necessarily, and that's the focus of your question. Where do the terms not overlap?

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... diversity (this is important in, for example, immunity). However, in a lot of cases (particularly in important proteins such as p53 -> a tumor suppressor protein) most alleles are preferred to be functioning. An allele that can produce an acceptable amount of protein product without both copies ...

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... chromatin states may lead to genomic instability, enhanced mutations rates, loss of imprinting, oncogene overexpression or silencing of tumor suppressor genes" from an article (not on germ cells, but I imply) http://www.ncbi.nlm.nih.gov/pubmed/18487951?ordinalpos=1&itool=PPMCLayout.PPMCAppController.PPMCArticlePage.PPMCPubmedRA&linkpos=3 ...

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