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Suppressor t-cell

suppressor T-cell

(Science: immunology) See t-cells.


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LOH/somatic inactivation/biallelic inactivation?

... or separate? If you're heterozygous, does somatic/biallelic inactivation not always lead to loss of heterozygosity? e.g. "The tumour suppressor gene p53 is frequently inactivated in gastric carcinoma by loss of heterozygosity (LOH), missense mutations and frame shift deletions" ...

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by Mike72
Thu Mar 01, 2012 4:04 pm
 
Forum: Genetics
Topic: LOH/somatic inactivation/biallelic inactivation?
Replies: 0
Views: 1656

BRCA1 Gene - Breast cancer and non-breast cells

... to cancer biology class. The BRCA1 gene was discussed and it was mentioned that it is causative (?) for breast cancer. However, it is a tumor suppressor of sorts and is present in all the cells. Then what happens when it comes to other cells? Why does a defect in this particular gene does ...

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by dharavsolanki
Tue Jan 18, 2011 10:48 am
 
Forum: Genetics
Topic: BRCA1 Gene - Breast cancer and non-breast cells
Replies: 0
Views: 899

Difference between proto-oncogenes and tumor supressor genes

There is some overlap - a tumor suppressor could be a proto-oncogene. But not necessarily, and that's the focus of your question. Where do the terms not overlap?

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by Darby
Tue Mar 16, 2010 2:12 pm
 
Forum: Human Biology
Topic: Difference between proto-oncogenes and tumor supressor genes
Replies: 2
Views: 3312

Alleles

... diversity (this is important in, for example, immunity). However, in a lot of cases (particularly in important proteins such as p53 -> a tumor suppressor protein) most alleles are preferred to be functioning. An allele that can produce an acceptable amount of protein product without both copies ...

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by jyaron
Mon Nov 30, 2009 6:02 am
 
Forum: Cell Biology
Topic: Alleles
Replies: 6
Views: 4018

Passing on mutations?

... chromatin states may lead to genomic instability, enhanced mutations rates, loss of imprinting, oncogene overexpression or silencing of tumor suppressor genes" from an article (not on germ cells, but I imply) http://www.ncbi.nlm.nih.gov/pubmed/18487951?ordinalpos=1&itool=PPMCLayout.PPMCAppController.PPMCArticlePage.PPMCPubmedRA&linkpos=3 ...

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by kolean
Wed Nov 18, 2009 11:58 pm
 
Forum: Evolution
Topic: Passing on mutations?
Replies: 8
Views: 4434
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