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Suppressor T-cells

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what is polycombrepress region ?

... development, and cell fate decisions. PRC2 target genes include important regulators of development and proliferation as well as tumor suppressor genes. Consistent with this, the activity of several Polycomb group (PcG) proteins is deregulated in human cancer suggesting an important ...

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by canalon
Thu Mar 15, 2012 1:22 pm
 
Forum: Molecular Biology
Topic: what is polycombrepress region ?
Replies: 1
Views: 969

LOH/somatic inactivation/biallelic inactivation?

... or separate? If you're heterozygous, does somatic/biallelic inactivation not always lead to loss of heterozygosity? e.g. "The tumour suppressor gene p53 is frequently inactivated in gastric carcinoma by loss of heterozygosity (LOH), missense mutations and frame shift deletions" ...

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by Mike72
Thu Mar 01, 2012 4:04 pm
 
Forum: Genetics
Topic: LOH/somatic inactivation/biallelic inactivation?
Replies: 0
Views: 1539

p16 in NCBI

Hi everyone, Can somebody help me use the NCBI database in order to find "p16”? (a tumor suppressor gene involved in cell cycle regulation). I know that its official gene symbol is “CDKN2A”. I would also need to know what other aliases this gene has, as well as the ...

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by elodiegillain
Mon Jan 10, 2011 7:59 pm
 
Forum: Genetics
Topic: p16 in NCBI
Replies: 1
Views: 986

Difference between proto-oncogenes and tumor supressor genes

There is some overlap - a tumor suppressor could be a proto-oncogene. But not necessarily, and that's the focus of your question. Where do the terms not overlap?

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by Darby
Tue Mar 16, 2010 2:12 pm
 
Forum: Human Biology
Topic: Difference between proto-oncogenes and tumor supressor genes
Replies: 2
Views: 3257

Alleles

... diversity (this is important in, for example, immunity). However, in a lot of cases (particularly in important proteins such as p53 -> a tumor suppressor protein) most alleles are preferred to be functioning. An allele that can produce an acceptable amount of protein product without both copies ...

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by jyaron
Mon Nov 30, 2009 6:02 am
 
Forum: Cell Biology
Topic: Alleles
Replies: 6
Views: 3969
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