Dictionary » S » Suppressor



A compound that suppresses the effects of mutation or suppresses what would be a normal course of events.

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what is polycombrepress region ?

... development, and cell fate decisions. PRC2 target genes include important regulators of development and proliferation as well as tumor suppressor genes. Consistent with this, the activity of several Polycomb group (PcG) proteins is deregulated in human cancer suggesting an important ...

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by canalon
Thu Mar 15, 2012 1:22 pm
Forum: Molecular Biology
Topic: what is polycombrepress region ?
Replies: 1
Views: 1323

LOH/somatic inactivation/biallelic inactivation?

... or separate? If you're heterozygous, does somatic/biallelic inactivation not always lead to loss of heterozygosity? e.g. "The tumour suppressor gene p53 is frequently inactivated in gastric carcinoma by loss of heterozygosity (LOH), missense mutations and frame shift deletions" ...

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by Mike72
Thu Mar 01, 2012 4:04 pm
Forum: Genetics
Topic: LOH/somatic inactivation/biallelic inactivation?
Replies: 0
Views: 2080

BRCA1 Gene - Breast cancer and non-breast cells

... to cancer biology class. The BRCA1 gene was discussed and it was mentioned that it is causative (?) for breast cancer. However, it is a tumor suppressor of sorts and is present in all the cells. Then what happens when it comes to other cells? Why does a defect in this particular gene does ...

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by dharavsolanki
Tue Jan 18, 2011 10:48 am
Forum: Genetics
Topic: BRCA1 Gene - Breast cancer and non-breast cells
Replies: 0
Views: 981

p16 in NCBI

Hi everyone, Can somebody help me use the NCBI database in order to find "p16”? (a tumor suppressor gene involved in cell cycle regulation). I know that its official gene symbol is “CDKN2A”. I would also need to know what other aliases this gene has, as well as the ...

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by elodiegillain
Mon Jan 10, 2011 7:59 pm
Forum: Genetics
Topic: p16 in NCBI
Replies: 1
Views: 1129

Re: HEK293 cells fractionation

... everyone i am new . i want to say about HEK293 cells fractionation. The cell polarity regulator, human Scribble (hScrib), is a potential tumour suppressor whose loss is a frequent event in late-stage cancer development. hese results provide a clear mechanistic explanation of how hScrib can regulate ...

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by harrygail87
Wed Dec 22, 2010 11:55 am
Forum: Cell Biology
Topic: HEK293 cells fractionation
Replies: 1
Views: 2413
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