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Substrate-level phosphorylation



A type of phosphorylation in which the phosphoryl group is transferred from a donor compound (a phosphorylated reactive intermediate) to the recipient compound


Substrate-level phosphorylation is one of the ways in which a phosphate group is introduced into a molecule. Another is oxidative phosphorylation.

In substrate-level phosphorylation, the PO43- from a phosphorylated substrate is transferred to ADP to form ATP. Phosphorylases and kinases catalyse this process. This is what happens during glycolysis in contrast to oxidative phosphorylation involving the electron transport chain and proton motive force.


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Re: TCA inhibitor

... but look closely at where the electron transport chain in oxidative phosphorylation. On the inner membrane of the mitochondrion, Succinate dehydrogenase ... much after the coupled coenzyme Q process, a totally different substrate by then, formed after many catabolism processes.So, when the new ...

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by billyfisher100
Fri Jan 20, 2012 1:21 am
Forum: Cell Biology
Topic: TCA inhibitor
Replies: 3
Views: 8114


... are what occur in the mitochondria. That is Krebs cycle and oxidative phosphorylation, excluding glycolisis that occurs in the cytoplasm. What ... you was incorrect. Cellular respiration refers to the oxidation of a substrate with the end goal of high energy products that can provide "energy" ...

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by daniel.kurz
Fri Nov 18, 2011 3:07 pm
Forum: Cell Biology
Topic: Mitochondrial energy pathways
Replies: 9
Views: 7813

Oxidative Phosphorylation

... 2 ? 2) http://i53.tinypic.com/2i8ga6o.png In the graph above where oxygen uptake by mitochondria in the presence of glutamate as a substrate, which compound inhibits the flow of electrons into complex 1 ? So far I've concluded: 1.a) Rotenone 1.b) Rotenone 1.c) Antimycin Can someone ...

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by uer23
Wed Mar 16, 2011 8:16 pm
Forum: Molecular Biology
Topic: Oxidative Phosphorylation
Replies: 1
Views: 2147

membrane-bound enzyme?

... on the outside of the cell that acts like a receptor for a molecular substrate (usually called ligand) to bind to it. This will cause a reaction ... and this produces a new reaction to the inside of the cell (such as phosphorylation or proton (H+) pumping).

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by kolean
Sun Dec 27, 2009 10:03 pm
Forum: Molecular Biology
Topic: membrane-bound enzyme?
Replies: 9
Views: 12672

a couple of review questions

... - because it is diluted in the enviroment? - substrate-based phosphorylation (look at glycolysis) and ATPase http://www.lmgtfy.com/?q=electron+transport ...

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by JackBean
Sat Nov 07, 2009 1:06 am
Forum: Microbiology
Topic: a couple of review questions
Replies: 1
Views: 1452
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