Dictionary » S » Substitution mutation

Substitution mutation

Definition

A type of point mutation in which a single nucleotide is substituted with (or exchanged for) a different nucleotide that may result in an altered sequence of amino acid during translation, which may render the newly synthesized protein ineffective.


Supplement

Examples of base-pair substitutions: purine substituted with a different purine (A → G) or a pyrimidine for a different pyrimidine (C → T). This type of substitution mutation is transition. Another kind is transversion, which is less common. In transversion, purine is substituted with pyrimidine or a pyrimidine with a purine.


See also: point mutation.


Please contribute to this project, if you have more information about this term feel free to edit this page



Results from our forum


Re: Increasing Information For Genetic Algorithm

... from the "optimum" will be selected against. The most mutation-resistant synonym will be selected for. If the new selective pressure ... grow it in presence of Kan... Also, you are misunderstanding synonymous substitution. It's random as any other mutation. It may affect levels of ...

See entire post
by Cat
Mon Sep 10, 2012 6:22 pm
 
Forum: Evolution
Topic: Increasing Information For Genetic Algorithm
Replies: 8
Views: 13003

Re: Re:

Rap: DNA does not evolve into mutation-resistant. Simply if the mutation would be lethal then nothing with mutated ... crucial function. See http://en.wikipedia.org/wiki/Synonymous_mutation#Synonymous_substitutions_and_evolution and google "synonymous substitution mutability" ...

See entire post
by JackBean
Mon Sep 10, 2012 3:08 pm
 
Forum: Evolution
Topic: Increasing Information For Genetic Algorithm
Replies: 8
Views: 13003

Re:

Rap: DNA does not evolve into mutation-resistant. Simply if the mutation would be lethal then nothing with mutated ... crucial function. See http://en.wikipedia.org/wiki/Synonymous_mutation#Synonymous_substitutions_and_evolution and google "synonymous substitution mutability" ...

See entire post
by Rap
Thu Sep 06, 2012 1:54 am
 
Forum: Evolution
Topic: Increasing Information For Genetic Algorithm
Replies: 8
Views: 13003

RFLP Question

... AS-heterozygous carrier SS-homozygous sickled The sickle cell mutation is caused by a single point mutation, (base substitution), in one of the exons that code for the synthesis of hemoglobin. All humans being ...

See entire post
by ramblingsloth
Sun Jun 03, 2012 3:13 pm
 
Forum: Molecular Biology
Topic: RFLP Question
Replies: 1
Views: 3190

Theories - Origin of Life

... tetramer. There are four subunits: two betas and two alphas. The point mutation I referred to earlier causes the beta chains to be wonky. As I said, ... located. Variants of these genes have been described. We know the exact substitution that occurs. People with certain variants have sickle-shaped ...

See entire post
by Luxorien
Sat Mar 10, 2012 5:03 pm
 
Forum: Evolution
Topic: Theories - Origin of Life
Replies: 562
Views: 929046
View all matching forum results

This page was last modified 00:53, 16 October 2008. This page has been accessed 93,960 times. 
What links here | Related changes | Permanent link