Dictionary » S » Substitution

Substitution

substitution

1. The act of putting one thing in the place of another, especially the chemical replacement of one element or radical by some other.

2. A defense mechanism, operating unconsciously, in which an unattainable or unacceptable goal, emotion or object is replaced by one that is attainable or acceptable.

Origin: L. Substitutio, from statuere = to place


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RNA

I think the answer to question 2 is formation of chimeric proteins because insertion, deletion and substitution are possible consequences of RNA splicing.

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by revision
Mon Nov 26, 2012 12:01 pm
 
Forum: Molecular Biology
Topic: RNA
Replies: 6
Views: 14244

RNA

... may not be consequences of RNA splicing 1. Insertion of amino acids in the protein sequence 2. Deletion of amino acids in the protein sequence 3. Substitution of amino acids in the protein sequence 4. Formation of chimeric proteins maybe 4? Ques 3: What are the potential outcome of RNA editing ...

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by 2468
Tue Nov 20, 2012 6:03 pm
 
Forum: Molecular Biology
Topic: RNA
Replies: 6
Views: 14244

MUSCLE multiple sequence alignment substitution matrix

I'm using MUSCLE to construct a multiple sequence alignment. Problem is, I have no idea what amino acid substitution matrix MUSCLE uses (I'm using the online version of MUSCLE, here: http://www.ebi.ac.uk/Tools/msa/muscle/). In short, I don't see anyplace that I can change the ...

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by MolBioRox
Tue Sep 18, 2012 9:52 pm
 
Forum: Bioinformatics
Topic: MUSCLE multiple sequence alignment substitution matrix
Replies: 0
Views: 1660

Re: Increasing Information For Genetic Algorithm

... would not know that some of your bacteria became Kan resistant until you grow it in presence of Kan... Also, you are misunderstanding synonymous substitution. It's random as any other mutation. It may affect levels of translation of some genes. If it does so in any great extent, especially if ...

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by Cat
Mon Sep 10, 2012 6:22 pm
 
Forum: Evolution
Topic: Increasing Information For Genetic Algorithm
Replies: 8
Views: 12352

Re: Re:

... the first one can freely mutate untill it will get some new crucial function. See http://en.wikipedia.org/wiki/Synonymous_mutation#Synonymous_substitutions_and_evolution and google "synonymous substitution mutability" and "silent substitution mutability" (without quotes) ...

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by JackBean
Mon Sep 10, 2012 3:08 pm
 
Forum: Evolution
Topic: Increasing Information For Genetic Algorithm
Replies: 8
Views: 12352
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