A large cell mass, crescentic on transverse section, extending forward over the dorsal surface of the crus cerebri from the rostral border of the pons into the subthalamic region; it is composed of a dorsal stratum of closely spaced pigmented (i.e., melanin-containing) cells, the pars compacta, and a larger ventral region of widely scattered cells, the pars reticulata; the pars compacta in particular includes numerous cells that project forward to the striatum (caudate nucleus and putamen) and contain dopamine, which acts as the transmitter substance at their synaptic endings; other, apparently non-dopaminergic cells of the substantia nigra project to a rostral part of the ventral nucleus of thalmus, the middle layers of the superior colliculus and to restricted parts of the reticular formation of the midbrain; the nigrostriatal projection is reciprocated by a massive striatonigral fibre system with multiple neurotransmitters, chief among which is gamma-aminobutyric acid (gABA); substantia n. Receives smaller afferent projections from the subthalamic nucleus, the lateral segment of the globus pallidus, the dorsal nucleus of the [[raph 5ea e]] and the pedunculopontine nucleus of the midbrain. The pars reticulata forms part of the output system for the striate body. The substantia n. Is involved in the metabolic disturbances associated with parkinson's disease and huntington's disease.
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... in embryogenesis and tissue renewal in adult, have been observed in nigral dopaminergic neurons in patients with Parkinson's disease. In the ... for apoptotic and autophagic features in melanized neurons of the substantia nigra in four normal aged subjects. Morphological characteristics ...
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... to carry out this they need to have dopamine which is released by the Substantia nigra. In this disease the substantia nigra is damaged, this means that the dopamine is not ...
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