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Stop codon

stop codon --> termination codon

(Science: molecular biology) The three codons, UAA known as ochre, UAG as amber and UGA as opal, that do not code for an amino acid but act as signals for the termination of protein synthesis.

They are not represented by any tRNA and termination is catalysed by protein release factors. There are two release factors in e. Coli, RF1 recognises UAA and UAG, RF2 recognises UAA and UGA. Eukaryotes have a single gTP requiring factor, eRF.

See: ochre suppressor, amber suppressor.


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Re: How dominance works at the DNA/RNA/protein

... leading to significantly reduced half-life of the mRNA. There may be STOP codon in middle of the gene yielding truncated protein. The protein may have mutated residue ...

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by JackBean
Thu Oct 04, 2012 11:58 am
 
Forum: Genetics
Topic: How dominance works at the DNA/RNA/protein
Replies: 10
Views: 2050

Can I deduce the Number of Proteins Produced?

... acid is coded by 3 nucleotides, and each open reading frame ends by a stop codon that doesn't code for any AA. I know that: The length of the Genome is 9.7 x 10^6 base ...

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by blah484
Thu Jun 28, 2012 3:53 pm
 
Forum: Genetics
Topic: Can I deduce the Number of Proteins Produced?
Replies: 1
Views: 1062

Re: How do we insert a polylinker in lacZ without inactivating i

... produce many more amino acids (assuming you don't clone in an in-frame stop codon).

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by jonmoulton
Mon Jun 04, 2012 11:22 pm
 
Forum: Genetics
Topic: How do we insert a polylinker in lacZ without inactivating i
Replies: 2
Views: 867

I need some actual DNA sequences for a computer program.

No, the gene is AUG AAA GGU AG... because the STOP codon is not in-frame, it won't be read. It will be like if there was none.

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by JackBean
Tue May 15, 2012 6:12 am
 
Forum: Molecular Biology
Topic: I need some actual DNA sequences for a computer program.
Replies: 7
Views: 1378

Molecular gene (genome) concept scientifically untenable

... Francis Crick formulated the “sequence hypothesis” (triplet code or codon, i.e., three bases at a time specified one amino acid) and the “central ... but they usually contain obvious disablements such as frameshifts or stop codons in the middle of coding domains. This prevents them from producing ...

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by PAWahid
Wed May 02, 2012 4:54 am
 
Forum: Molecular Biology
Topic: Molecular gene (genome) concept scientifically untenable
Replies: 12
Views: 11392
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