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Sticky end


noun, plural: sticky ends

(molecular biology) A fragment of DNA (often produced by a staggered cut on the DNA using restriction enzymes) in which the terminal portion has a stretch of unpaired nucleotides, and the strands are not of the same length.


The ends of the DNA are sticky because it can easily match up with a complementary overhang.

For example, these two sticky ends can be joined together since they can form complementary base pairs in the overhang region:


Synonym: DNA end, cohesive end.
Compare: blunt end.
See also: restriction enzyme, overhang (molecular biology).

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Re: Odd food poisoning-like symptoms, strange tastes

... let it run its course. I've had it twice, now. The first time was a couple weeks ago. My vomit and diarrhea were very dark brown with a seemingly sticky consistency. I only vomitted twice (in one sitting) with the first time. This second time from which I am currently recovering I was dry heaving ...

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by HungryHippo
Wed Nov 27, 2013 11:58 pm
Forum: Human Biology
Topic: Odd food poisoning-like symptoms, strange tastes
Replies: 35
Views: 136559

Telomere and DNA replication

... is shorter owing to lost telomeres. I have discoerved, from private research, that telomere binding proteins prevent exonucleases degrading the sticky ends of the parent strand. As such when the second generation of cells divides the third generation will have 2 (out of a total of 8) cells with ...

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by jsmith613
Sun Oct 06, 2013 11:10 pm
Forum: Genetics
Topic: Telomere and DNA replication
Replies: 0
Views: 1870

Structure of flower

... gametophyte with a protective outer covering. Carpel\Pistil Female part of the flower. Consisting of the stigma, style and ovary. Stigma Often sticky top of carpel, serves as a receptive surface for pollen grains. Style The stalk of a carpel, between the stigma and the ovary, through which ...

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by snowfall
Thu May 30, 2013 5:29 pm
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Topic: Structure of flower
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Campylobacter RFLP troubleshooting

Wait a sec. So you amplify your GOI and then cut it with RE for what exactly? Just at the ends to make sticky ends for consequent cloning? And I guess you use your PCR reaction without any purification?

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by JackBean
Sun May 05, 2013 3:54 pm
Forum: Molecular Biology
Topic: Campylobacter RFLP troubleshooting
Replies: 4
Views: 2818


... ratio between insert and vector changes whether you have an cohesive (sticky) end insert or a blunt end insert. Generally while we're doing blunt end insert-vector ligation ...

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by genetherapy
Mon Jul 16, 2012 3:11 pm
Forum: Molecular Biology
Replies: 9
Views: 7033
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