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Signal peptides

signal peptides

additional polypeptide sequence of 25 to 30 residues at the amino-terminal or carboxy-terminal end of proteins. The signal sequence signals the cellular fate or destination of a newly synthesised protein directing it to its ultimate destination in the cell. These leaders are recognised by the signal recognition particle and bound by specific receptor sites on the outer surface of the endoplasmic reticulum. They are then transported into the cisterna of the endoplasmic reticulum and from there directed to their ultimate destination in the cell. In prokaryotes, the signal peptides attach to the plasma membrane. These signal sequences are ultimately removed by specific peptidases.


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LIC PCR Primer with Signal Peptide?

... I know what you mean. It would appear from the NCBI database that the signal peptide was included as part of the particular protein I searched ... then on it became clear what was happening here. Any idea why signal peptides are included in protein searches or was this a once off?

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by stalinsma
Wed Oct 19, 2011 8:17 pm
 
Forum: Molecular Biology
Topic: LIC PCR Primer with Signal Peptide?
Replies: 3
Views: 2695

Re: Gene cloning question

... you're probably best off starting with 5-10. Also, most of these signal peptides are at the N- or C- terminus, not in the middle of the protein, and the probability ...

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by MrMistery
Sat Aug 01, 2009 3:08 am
 
Forum: Molecular Biology
Topic: Gene cloning question
Replies: 20
Views: 17685

The Fiber Disease

... number of potential antigen-binding sites by displaying random peptides fused to major coat protein pVIII. We constructed libraries with ... agents and, as a part of an analytical platform, generates a detectable signal. As elements of field-use detectors, they are superior to monoclonal ...

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by London
Mon Dec 11, 2006 8:19 pm
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5488962

The Fiber Disease

... says Kämper. wait.... The mammalian cell constantly receives signals from its surroundings to which it has to respond appropriately. Growth ... sequence: (1) non-cleavable, membrane-spanning sequences, (2) signal peptides with signal peptidase (SPase) I-like cleavage sites, and (3) signal ...

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by Nadas Moksha
Tue Nov 14, 2006 5:17 am
 
Forum: Human Biology
Topic: The Fiber Disease
Replies: 7403
Views: 5488962

morgellons disease

... configurations) used in partitioning membranes with probes attached to signal cell changes, benzoic acid, dimethyl, accutane, isotretinoin, trentioin, ... open up capillaries and travel through the pores of skin. they used peptides and they have nasal peptide delivery agents. i came across these ...

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by justice blackwood
Sat Nov 04, 2006 3:07 am
 
Forum: Human Biology
Topic: morgellons disease
Replies: 1
Views: 2937
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