Dictionary » S » Signal peptide

Signal peptide

Definition

noun

An extra-peptide extension found at the amino terminus of a nascent protein, and functions by prompting the transport mechanism within the cell to bring it to its specific destination within the cell, i.e. the endoplasmic reticulum into the secretory pathway


Supplement

Signal peptide, commonly comprised of a chain of approximately 20 amino acids, is essential because it directs the protein where it should go. If the protein is for secretion (transport outside the cell), then, the signal peptide is necessary to direct the protein to the endoplasmic reticulum where it will grow further and mature to ready for secretion. The signal peptide is recognized by the signal recognition particle (SRP) and cleaved by the signal peptidase following transport at the endoplasmic reticulum.


Synonym(s):

See also:

Reference(s):

  • 1 Duffaud GD, Lehnhardt SK, March PE, Inouye M. 1985. Structure and Function of the Signal Peptide. In: Knauf PA, Cook JS. Membrane protein biosynthesis and turnover. Florida: Academic Press. P.65-104.

Please contribute to this project, if you have more information about this term feel free to edit this page



Results from our forum


What makes dominant allele dominant?

... several options, you can have premature STOP codon and the resulting peptide is too short to do its work. Or you can have change of a crucial ... in receptor which impair its ability to transfer phosphates and thus signal the binding. Or you could change the post-translational modification ...

See entire post
by JackBean
Thu Feb 27, 2014 5:20 pm
 
Forum: Genetics
Topic: What makes dominant allele dominant?
Replies: 7
Views: 3953

Biology question help?

... is 1 2,Which of the following proteins are least likely to contain a signal peptide? Options: 1.Cytosolic proteins 2. Nuclear Proteins 3. Secretory proteins 4. Membrane ...

See entire post
by revision
Sat Dec 08, 2012 6:24 pm
 
Forum: Molecular Biology
Topic: Biology question help?
Replies: 5
Views: 3079

Sequencing question/primer design

no, signal peptide is on protein sequence. You need to analyse it on-line to see whether there is some predicted signal peptide ...

See entire post
by JackBean
Mon Nov 05, 2012 10:47 am
 
Forum: Molecular Biology
Topic: Sequencing question/primer design
Replies: 4
Views: 3186

Re:

... sequence ATG GTC ATC GTC TGA GTC and first three amino acids belong to signal peptide (in reality it's much longer). In such case, you want your primer to start at GTC and ...

See entire post
by coppcw08
Mon Nov 05, 2012 12:27 am
 
Forum: Molecular Biology
Topic: Sequencing question/primer design
Replies: 4
Views: 3186

Sequencing question/primer design

... sequence ATG GTC ATC GTC TGA GTC and first three amino acids belong to signal peptide (in reality it's much longer). In such case, you want your primer to start at GTC and ...

See entire post
by JackBean
Sun Nov 04, 2012 11:19 pm
 
Forum: Molecular Biology
Topic: Sequencing question/primer design
Replies: 4
Views: 3186
View all matching forum results

This page was last modified 13:14, 11 August 2011. This page has been accessed 18,668 times. 
What links here | Related changes | Permanent link